grant
Cross-species transfer learning for liquid biopsy-based cancer detection
Organization UNIVERSITY OF CALIFORNIA AT DAVISLocation DAVIS, UNITED STATESPosted 4 May 2026Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY20260-11 years oldAddressAdversarial model trainingAdversarial trainingAnimal ModelAnimal Models and Related StudiesArchitectureBiochemicalBiologicalBiological MarkersBiopsy SampleBiopsy SpecimenBlood PlasmaBone CancerBone SarcomaCancer DetectionCancer DiagnosticsCancersCanine SpeciesCanis familiarisChildChild YouthChildren (0-21)ClinicalClinical ResearchClinical StudyDataData SetDevelopmentDevelopment and ResearchDiagnosticDiseaseDisease ProgressionDisorderDogsDogs MammalsEarly DiagnosisEngineeringEngineering / ArchitectureEnsureFaceFoundationsGoalsHumanIR/UV/Raman SpectroscopyImaging ProceduresImaging TechnicsImaging TechniquesIndividualInterdisciplinary ResearchInterdisciplinary StudyKnowledgeLabelLearningMachine LearningMalignant Bone NeoplasmMalignant NeoplasmsMalignant Osseous NeoplasmMalignant Osseous TumorMalignant TumorMalignant Tumor of the BoneMapsMasksMedicineMetabolicModelingModern ManMolecularMonitorMultidisciplinary CollaborationMultidisciplinary ResearchNeoplasmsNon-Invasive Cancer DetectionNon-Polyadenylated RNANoninvasive Cancer DetectionOncologyOncology CancerOrphan DiseaseOsseous CancerOsseous SarcomaOsteogenic SarcomaOsteosarcomaPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPerformancePlasmaPlasma SerumPopulationProspective StudiesR & DR&DRNARNA Gene ProductsRaman SpectroscopyRaman Spectrum AnalysisRaman imagingRaman spectrometryRare DiseasesRare DisorderResearchResearch SupportReticuloendothelial System, Serum, PlasmaRibonucleic AcidRiskSample SizeSamplingSightSkeletal SarcomaSolidSystemTechniquesTestingTrainingTranslatingValidationVariantVariationVisionWorkadversarial approachadversarial learningadversarial strategyanalogautoencoderautoencoding neural networkbio-markersbiologicbiologic markerbiomarkerbiomarker arraybiomarker panelcancers that are rarecaninecanine animal modelcanine modelcell free DNAcell free circulating DNAclinical diagnosticsclinical translationclinically translatablecohortcompanion animalcompanion petcomparativecostdata acquisitiondata acquisitionsdata to traindataset to traindevelopmentaldiagnostic developmentdiagnostic platformdiagnostic systemdiagnostic tooldisease controldisease diagnosticdisorder controldog modeldomestic dogearly detectionfacesfacialflexibilityflexiblehuman datahuman diseaseimprovedindependent learninginnovateinnovationinnovativekidslearning activitylearning methodlearning strategieslearning strategylipidomicsliquid biopsymachine based learningmachine learning based modelmachine learning modelmalignancymarker panelmedical diagnosticmetabolism measurementmetabolomicsmetabonomicsmodel of animalmultiomicsmultiple omicsneoplasianeoplasm/cancerneoplastic growthnext generationorphan disorderosteochondrosarcomaosteoid sarcomapanomicspatient oriented outcomespatient populationpre-clinicalpreclinicalprognosticprognosticationprospective research studyprospective surveyrare cancerrare malignancyrare tumorreal time monitoringrealtime monitoringresearch and developmentself supervisedself supervised learningself supervisionself-directed learningself-regulated learningshot learningtargeted biomarkertooltool developmenttraining datatraining datasetstransfer learningtranslation to humansvalidationsvisual functionyoungster
Description preview
PROJECT SUMMARY
There is a crucial need in the field of advanced diagnostic tool development for early detection of rare cancers
such as osteosarcoma (OSA). Specifically, there is a need to develop platforms that can overcome the
limitations of small sample sizes inherent in rare cancers while maintaining generalizability across patient…
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