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CRISPR RNA-guided recognition of invading RNA activates a multipronged cell death response
Organization MONTANA STATE UNIVERSITY - BOZEMANLocation BOZEMAN, UNITED STATESPosted 1 Jan 2024Deadline 31 Dec 2025 ⚠️
NIHUS FederalResearch GrantFY2025Adaptive Immune SystemAffinityArchaeaArchaebacteriaArchaeobacteriaArchaeonAssayBacteriaBacteriophagesBindingBioassayBiochemicalBiochemistryBiologicalBiological AssayBiological ChemistryBiological FunctionBiological ProcessCell AgingCell Communication and SignalingCell DeathCell SenescenceCell SignalingCellular AgingCellular SenescenceChimera ProteinChimeric ProteinsCoACoenzyme ACollaborationsComplexComputing MethodologiesConflictConflict (Psychology)Cryo-electron MicroscopyCryoelectron MicroscopyCyclicityDNADNA cassetteDefense MechanismsDeoxyribonucleic AcidDetectionDevelopmentDouble-Stranded DNAEMSAEarthElectron CryomicroscopyElementsFamilyFellowshipFusion ProteinFusion ToxinGene ProteinsGenesGeneticGuide RNAImmuneImmune responseImmune signalingImmune systemImmunesIn VitroIncubatedInfectionIntracellular Communication and SignalingInvadedInvestigatorsLinkMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMeasuresMediatingMemoryMessenger RNAMolecularMolecular ConfigurationMolecular ConformationMolecular InteractionMolecular StereochemistryNon-Polyadenylated RNANucleic AcidsOther GeneticsParasitesPeriodicityPhagesPhylogenetic AnalysisPhylogeneticsPlanet EarthPolymerasePopulationPredatory BehaviorProductivityProtein BiosynthesisProtein Gene ProductsProteinsRNARNA BindingRNA Gene ProductsRNA boundRadiolabeledReplicative SenescenceResearchResearch PersonnelResearchersResolutionRhythmicityRibonucleic AcidRibonucleoproteinsRibosomal Peptide BiosynthesisRibosomal Protein BiosynthesisRibosomal Protein SynthesisRibosomesScientistSignal TransductionSignal Transduction SystemsSignalingSignaling MoleculeStructureSystemTestingToxinTrainingTranscriptTransfer RNATranslational InhibitionTranslational RepressionTranslationsTriplet Codon-Amino Acid AdaptorViralViral DiseasesViral GeneticsVirusVirus DiseasesVirus ReplicationWorkacquired immune systemanti-toxinbacterial virusbiologicbiological signal transductioncareercomputational methodologycomputational methodscomputer based methodcomputer methodscomputing methodconformationconformationalconformational stateconformationallyconformationscryo-EMcryoEMcryogenic electron microscopydevelopmentalds-DNAdsDNAendonucleaseenhancer cassetteexperimentexperimental researchexperimental studyexperimentsexpression cassettegRNAgene cassettegenetic cassettehost responseimmune system responseimmunoresponseinsightintegration cassettemRNAnecrocytosisnoveloligoadenylatepredationpromoter cassetteprotein synthesispsychological defense mechanismpublic data basepublic databasepublicly accessible data basepublicly accessible databasepublicly available data basepublicly available databaseradiolabelingradiologically labeledreplicative agingreporter cassetteresistance cassetteresolutionsresponseselectable cassetteselection cassetteskillsstop cassettestructural biologytRNAtranscription cassettetranscriptional cassettetransfer Ribonucleic acidstransgene cassettetranslationtranslation assayviral infectionviral multiplicationviral replicationvirus geneticsvirus infectionvirus multiplicationvirus-induced disease
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Description preview
PROJECT SUMMARY
CRISPRs (Clustered, Regularly, Interspersed, Palindromic Repeats) and CRISPR-associated proteins (Cas)
are essential components of adaptive immune systems in bacteria and archaea that provide sequence-specific
protection from viruses and other genetic parasites. CRISPR systems are phylogenetically and functionally
diverse. Most of…
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