grant

Creation of a monkey mini mental state exam (mMMSE) for identifying early cognitive deficits related to Alzheimer’s disease and related dementias

Organization UNIVERSITY OF CALIFORNIA AT DAVISLocation DAVIS, UNITED STATESPosted 15 Aug 2022Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY202519 year old19 years of ageAD dementiaAD modelAD related dementiaADRDAffectiveAgeAgingAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's and related dementiasAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease modelAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease related dementiaAlzheimers DementiaAmentiaAnimal ModelAnimal Models and Related StudiesAnimalsBehavioralBehavioral SymptomsBiologicalBiological MarkersCaliforniaCardiacCaringCognitiveCognitive agingCognitive deficitsCorrelation StudiesDegenerative Neurologic DisordersDementiaDiseaseDisorderEarly InterventionEarly identificationEnrollmentExerciseGenetic studyGoalsHealthHigh Throughput AssayHourHumanIndividualIndividual DifferencesInterventionIntervention StrategiesInvestigatorsLaboratoriesLightLiteratureLong-term cohort studyLongitudinal StudiesLongitudinal cohort studyM mulattaM. mulattaMacaca mulattaMacaca rhesusMaintenanceMeasuresMemoryMental HealthMental HygieneModelingModern ManMonkeysNHP modelsNervous System Degenerative DiseasesNeural Degenerative DiseasesNeural degenerative DisordersNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsOutcomePathologyPerformancePersonal SatisfactionPersonsPhasePhotoradiationPrimary Senile Degenerative DementiaPrimatesPrimates MammalsProcessPsychological HealthResearchResearch PersonnelResearch ResourcesResearchersResourcesRhesus MacaqueRhesus MonkeyRiskRunningSamplingSampling StudiesScreening procedureStatistical CorrelationStructureStudy modelsSubgroupTestingTimeTrainingVariantVariationWorkaberrant agingabnormal agingage 19 yearsage associatedage associated alterationsage associated changesage associated diseaseage associated disorderage associated impairmentage correlatedage correlated alterationsage correlated changesage dependentage dependent alterationsage dependent changesage dependent diseaseage dependent disorderage dependent impairmentage induced alterationsage induced changesage linkedage relatedage related alterationsage related changesage related human diseaseage specificage specific alterationsage specific changesage-related diseaseage-related disorderage-related impairmentagesaging associated alterationsaging associated changesaging correlated alterationsaging correlated changesaging dependent alterationsaging dependent changesaging induced alterationsaging induced changesaging processaging related alterationsaging related changesaging specific alterationsaging specific changesalterations with agealzheimer modelbio-markersbiologicbiologic markerbiomarkerchanges with agecognitive assessmentcognitive defectscognitive functioncognitive testingdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdevelop therapydisease riskdisorder riskdysfunctional age related changedysfunctional agingemotional experienceenrollexercise interventionexperienceexperimentexperimental researchexperimental studyexperimentsfunctional statushigh throughput screeningimpaired agingimprovedindexingindividual heterogeneityindividual variabilityindividual variationinsightintervention developmentlife spanlifespanlong-term studylongitudinal outcome studiesmaladaptive agingmental statemental statusmodel of animalnatural agingneurodegenerative illnessnineteen year oldnineteen years oldnon-human primatenonhuman primatenonhuman primate modelsnormal agingnormative agingold agepathological age related changespathological agingphysical activity interventionphysical conditioningphysical healthprimary degenerative dementiapsychologicpsychologicalpsychological symptomscreeningscreening toolsscreeningssenile dementia of the Alzheimer typesocialsocial relationshipstherapy developmenttooltool developmenttreadmilltreatment developmentwell-beingwellbeing
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Description preview

Aging is a hugely variable process. Some people age well, with sustained memory, generally positive emotional experiences, healthy social relationships, and good physical health into old age, while others experience significant age-related detriments to both psychological and physical health. Predicting who is vulnerable to poor aging outcomes and…

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Creation of a monkey mini mental state exam (mMMSE) for identifying early cognitive deficits related to Alzheimer’s dise | Dev Procure