grant
CRCNS: The noradrenergic modulation during sleep: from circuits to memory
Organization UNIVERSITY OF CALIFORNIA, SAN DIEGOLocation LA JOLLA, UNITED STATESPosted 1 Mar 2026Deadline 28 Feb 2031
NIHUS FederalResearch GrantFY2026AD dementiaAdvanced DevelopmentAffectAgingAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimers DementiaAmmon HornArousalBehavior assessmentBehavioralBrainBrain Nervous SystemBrain StemBrain regionBrainstemCausalityCell BodyCell NucleusCellsCharacteristicsClinicalCognitiveCognitive DisturbanceCognitive ImpairmentCognitive ManifestationsCognitive SymptomsCognitive declineCognitive function abnormalCommon Rat StrainsCommunicationComputer ModelsComputerized ModelsCornu AmmonisCouplingDevelopmentDisturbance in cognitionDysfunctionEarly DiagnosisEarly InterventionElectrophysiologyElectrophysiology (science)EncephalonEtiologyEvaluationFast-Wave SleepFore-BrainForebrainFoundationsFunctional disorderGoalsHippocampusImpaired cognitionInstructionInterventionInvestigationLearningLevarterenolLevonorepinephrineLocus CoeruleusMediatingMemoryMemory DeficitMemory impairmentMental disordersMental health disordersModelingNE systemNREMNeocortexNerve CellsNerve UnitNervous System DiseasesNervous System DisorderNeural CellNeurocyteNeurologic DisordersNeurological DisordersNeuronsNeurophysiology / ElectrophysiologyNoradrenalineNorepinephrineNucleusNucleus Pigmentosus PontisParadoxical SleepPatternPhasePhysiopathologyPlayPopulationPrefrontal CortexPrimary Senile Degenerative DementiaProcessPropertyProsencephalonPsychiatric DiseasePsychiatric DisorderREM SleepRatRats MammalsRattusResearchRhombencephalic SleepRoleSchizophreniaSchizophrenic DisordersSiteSleepSleep DeprivationSleep Wake CycleSleep disturbancesStimulusSystemTestingThalamic structureThalamusTherapeuticaberrant sleepage associated effectsage effectage related effectsaging effectawakebehavioral assessmentblue nucleuscausationcognitive dysfunctioncognitive losscognitive performancecognitive taskcommon symptomcomputational modelingcomputational modelscomputer based modelscomputerized modelingdecline in functiondecline in functional statusdeficient sleepdementia praecoxdevelopmentaldisease causationdisrupted sleepdisturbed sleepdreaming sleepearly detectionelectrophysiologicalexperienceexperimentexperimental researchexperimental studyexperimentsfascinatefunctional declinefunctional status declinehippocampalhomotypical corteximpact of ageimpaired sleepinadequate sleepinfluence of ageinsufficient sleepinterestirregular sleepisocortexlocus ceruleus structurelong-term memorymemory consolidationmemory dysfunctionmemory encodingmental illnessmicrostimulationnatural agingneopalliumneuralneural controlneural regulationneurological diseaseneuromodulationneuromodulatoryneuronalneurophysiologicalneurophysiologyneuroregulationnew approachesnon rapid eye movementnon-REMnon-rapid eye movementnonREMnonrapid eye movementnoradrenergicnorepinephrine systemnormal agingnormative agingnovelnovel approachesnovel strategiesnovel strategyoptogeneticspathophysiologyprimary degenerative dementiapsychiatric illnesspsychological disorderquality of sleeprapid eye movement sleepresponseschizophrenicsenile dementia of the Alzheimer typesleep amountsleep debtsleep deficiencysleep deficitsleep disruptionsleep durationsleep dysregulationsleep episodesleep insufficiencysleep intervalsleep lengthsleep losssleep patternsleep periodsleep qualitysleep quantitysleep routinesleep schedulesleep timesleep to wake transitionsleep to wakefulness transitionsleep wakefulness cyclesleep/wake disruptionsleep/wake disturbancesleep/wake patternssleep/wake transitionssocial rolespatial and temporalspatial temporalspatiotemporalthalamictime asleeptime during sleeptime in sleeptime spent asleeptime spent sleepingtool
Description preview
PROJECT SUMMARY (See instructions):
The ultimate goal of this research is to understand how brain rhythms during Non-Rapid Eye Movement
(NREM) sleep relate to the replay of information encoded in the hippocampus, the subsequent transfer of
that information into cortical long-term memory, and how these processes are modulated by the Locus
Coeruleus…
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