grant
Cortical dystonia of prematurity
Organization WASHINGTON UNIVERSITYLocation SAINT LOUIS, UNITED STATESPosted 1 Aug 2025Deadline 31 May 2030
NIHUS FederalResearch GrantFY20250-11 years old21+ years oldAddressAdultAdult HumanAffectAgeAmericanAnti-CholinergicsAnticholinergic AgentsAnticholinergicsBehaviorBirthCerebral PalsyCerebrumChildChild YouthChildren (0-21)ChronicClinicalClozapineConnector NeuronCorpus StriatumCorpus striatum structureDataDevelopmentDisabling conditionDisabling health conditionDysfunctionDyskinesia SyndromesDystoniaEEGEarly treatmentElectroencephalogramElectroencephalographyEmbryoEmbryonicFiberFoundationsFunctional disorderFutureGABA ReceptorGeneticGestationGlutamatesHigh PrevalenceHumanIn VitroInjuryIntercalary NeuronIntercalated NeuronsInterneuronsInternuncial CellInternuncial NeuronL-GlutamateMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMeasurementMeasuresMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMethodsMiceMice MammalsModelingModern ManMovement Disorder SyndromesMovement DisordersMurineMusMuscle DystoniaNMR ImagingNMR TomographyNerve CellsNerve UnitNeural CellNeurocyteNeuronsNuclear Magnetic Resonance ImagingOutputOxidesPalsyParalysedParturitionParvalbuminsPathogenesisPathologyPathway interactionsPersonsPhotometryPhysiopathologyPlegiaPregnancyPremature BirthPrematurely deliveringPreterm BirthRoleScientific Advances and AccomplishmentsStriate BodyStriatumTestingWorkZeugmatographyadulthoodagescare costscerebralchildhood dystoniacholinergicclinical relevanceclinical validationclinically relevantcommon treatmentcostdevelopmentaldystonia in childrenearly therapyeffective therapyeffective treatmentextreme prematurityextremely premature infantextremely pretermextremely preterm infantgamma-Aminobutyric Acid Receptorsglutamatergichigh riskimmunoreactivityimprovedin vivoinjuriesinnovateinnovationinnovativekidsmouse modelmurine modelneuronalneuropathologicneuropathologicalneuropathologynovelparalysisparalyticpathophysiologypathwaypediatric dystoniapostnatalprematurepremature childbirthpremature deliveryprematuritypreterm deliverypreventpreventingpupreceptor bindingreceptor boundscientific accomplishmentsscientific advancessocial rolestriataltimelinetranslational studyvery prematurevery pretermyoungster
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PROJECT SUMMARY
Preterm birth is the most common cause of cerebral palsy (CP) in the US and, consequently, the most common
cause of childhood dystonia, a disabling condition affecting 2 of every 1000 Americans. Despite its high
prevalence, dystonia in CP remains difficult to treat because 1) it is hard to predict, preventing early treatment
when…
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