grant
Coronary Vascular Resilience by Modulation of Mitochondrial ROS in Endothelium
Organization RHODE ISLAND HOSPITALLocation PROVIDENCE, UNITED STATESPosted 1 Aug 2025Deadline 31 May 2029
NIHUS FederalResearch GrantFY2025ATP SynthesisATP Synthesis PathwayActive OxygenAddressAnimal ModelAnimal Models and Related StudiesAnimalsAntioxidantsApoplexyAssayAtrialBioassayBiogenesisBiological AssayBlood VesselsBody TissuesBrain Vascular AccidentCardiacCardiac AtriumCardiac Muscle CellsCardiac MyocytesCardiac SurgeryCardiac Surgery proceduresCardiac infarctionCardiocyteCardiovascular DiseasesCell Death InductionCell SurvivalCell ViabilityCerebral StrokeCerebrovascular ApoplexyCerebrovascular StrokeChronicCitric Acid CycleClottingCoagulationCoagulation ProcessComplexCongressesCoronaryCoronary ArteriosclerosisCoronary Artery DiseaseCoronary Artery DisorderCoronary AtherosclerosisCoronary VesselsD-GlucoseDataDependenceDextroseEC 1.1.1.27EchocardiogramEchocardiographyElectron TransportEndothelial CellsEndotheliumEnergy SupplyFamily suidaeFibrinGenerationsGenus HippocampusGlucoseGlycolysisH2O2Heart AtriumHeart Muscle CellsHeart Surgical ProceduresHeart myocyteHumanHydrogen PeroxideHydroperoxideIPO-BIndophenol Oxidase BInfarctionIschemiaIschemic HeartIschemic Heart DiseaseIschemic myocardiumKnock-outKnockoutKrebs CycleL-Lactate DehydrogenaseL-Lactic Acid DehydrogenaseLactate DehydrogenaseMNSODManganese Superoxide DismutaseMeasurementMediatingMesenchymalMiceMice MammalsMitochondriaMitochondrial Superoxide DismutaseMn Superoxide DismutaseMn-SODModelingModern ManMolecularMorbidityMorbidity - disease rateMurineMusMyocardial InfarctMyocardial InfarctionMyocardial IschemiaNAD-Lactate DehydrogenaseNational Institutes of HealthO elementO2 elementOrigin of LifeOutcomeOxidantsOxidative PhosphorylationOxidative Phosphorylation PathwayOxidizing AgentsOxygenOxygen RadicalsPatientsPigsPro-OxidantsProductionProliferatingProteomicsPyruvateReactive Oxygen SpeciesRecoveryRecyclingReportingResearchRoleSOD2SOD2 geneSeahorseStrokeSuidaeSuperoxide AnionSuperoxide Dismutase 2Superoxide RadicalSuperoxidesSwineSystemTCA cycleTissuesTransgenic OrganismsTransthoracic EchocardiographyTricarboxylic Acid CycleUnited States National Institutes of HealthVascular EndotheliumWorkameroidangiogenesisatherosclerotic coronary diseasebrain attackcardiac functioncardiac infarctcardiac ischemiacardiomyocytecardiovascular disordercerebral vascular accidentcerebrovascular accidentcomplex IVcoronary arterial diseasecoronary attackcoronary infarctcoronary infarctioncoronary ischemiadensityelectron acceptorelectron transferenergy efficiencyfunction of the heartglutathione peroxidaseheart attackheart functionheart infarctheart infarctionheart ischemiaheart sonographyheart surgeryimprovedin vivoinfarctinnovateinnovationinnovativelactic acid dehydrogenasemitochondrialmodel of animalmyocardial ischemia/hypoxiamyocardium ischemianano particlenano-sized particlenanoparticlenanosized particleoverexpressoverexpressionporcinepreservationresilienceresilientsocial rolespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicsstrokedstrokessuidtransgenictranslational opportunitiestranslational potentialtrendvascular
Description preview
The main objective of this study is to elucidate molecular mechanisms by which coronary endothelial cells
(EC) can survive and proliferate in ischemic (low oxygen, low glucose) conditions and help improve cardiac
This proposal is based on our recent report that
reduction in mitochondrial (mito)-ROS, using EC-specific transgenic overexpression of…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click