grant
Core D-Get IN
Organization NORTHWESTERN UNIVERSITYLocation CHICAGO, UNITED STATESPosted 20 Aug 2019Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY20253-D3-Dimensional3D3D cell culture3D cultureBiocompatible MaterialsBiologyBiomaterialsBody TissuesCRISPRCRISPR activationCRISPR activatorCRISPR approachCRISPR based activationCRISPR based approachCRISPR editing screenCRISPR gene activationCRISPR interferenceCRISPR methodCRISPR methodologyCRISPR screenCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR transcription activationCRISPR transcriptional activationCRISPR-CAS-9CRISPR-Cas-9-mediated gene activationCRISPR-based gene activationCRISPR-based methodCRISPR-based screenCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR-dCAS9 ActivatorCRISPR-dCas9-mediated repressionCRISPR-mediated transcriptional activationCRISPR/CAS approachCRISPR/CAS9 activationCRISPR/CAS9 gene activationCRISPR/Cas methodCRISPR/Cas systemCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 screenCRISPR/Cas9 technologyCRISPR/dCas9 activationCRISPR/dCas9 interferenceCRISPR/dCas9-based transcriptional activationCRISPR/dCas9-mediated transcriptional inhibitionCRISPRaCRISPRiCas nuclease technologyCell BodyCell LineCell NucleusCellLineCellsClustered Regularly Interspaced Short Palindromic RepeatsClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats interferenceClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCollaborationsComplementary DNAComplexConsultationsCounselingCutaneous DisorderDNADNA TherapyDNA deliveryDeoxyribonucleic AcidDermatosesDiseaseDisorderDrug DeliveryDrug Delivery SystemsEducationEducational aspectsEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEpithelial CellsEquipmentExperimental DesignsGene ExpressionGene ModifiedGene Transfer ClinicalGenesGeneticGenetic InterventionGenetic MaterialsGenetic ScreeningGoalsGrantGuide RNAHDLHDL LipoproteinsHeavy LipoproteinsHigh Density LipoproteinsHumanIn VitroIndividualInvestigatorsLibrariesLipoproteinsMediatingMethodsMiceMice MammalsMissionModern ManModificationMurineMusNIAMSNanotechnologyNational Institute of Arthritis, and Musculoskeletal, and Skin DiseasesNon-Polyadenylated RNANucleusOrganismProductivityProteinsRNARNA Gene ProductsReagentReproducibilityResearchResearch PersonnelResearch ResourcesResearchersResourcesRibonucleic AcidScientistServicesShort interfering RNASkinSkin DiseasesSkin Diseases and ManifestationsSmall Interfering RNASpherical Nucleic AcidsStrains Cell LinesSystemTherapeutic InterventionTissuesToxic effectToxicitiesTranslational ResearchTranslational ScienceUniversitiesViralViral Vectoractivating CRISPR technologyalpha-Lipoproteinsbase editingbench-to-bedside translationbiological materialcDNAclinical investigationclinical relevanceclinically relevantclustered regularly interspaced short palindromic repeats screenconsultationcultured cell linecutaneous barriercutaneous diseasedeliver DNAdepositorydermal barrierdermal diseasedermal disorderdiscover genesepidermal barrierepigeneticallyepigenomicsgRNAgain of functiongene discoverygene functiongene manipulationgene modificationgene repair therapygene therapygene-based therapygenetic approachgenetic manipulationgenetic strategygenetic therapygenetically manipulategenetically modifiedgenetically perturbgenome editinggenome scalegenome wide screengenome-widegenomewidegenomic editinggenomic therapygenomic toolshuman modelin vivoinnovateinnovationinnovativeintervention therapyknock-downknockdownknockout geneliving systemloss of functionmembermodel of humannano technano technologynano-technologicalnanocarriernanolipoprotein particlesnanotechnanotechnologicalnanovesselnew approachesnovelnovel approachesnovel strategiesnovel strategynucleofectionoverexpressoverexpressionpre-clinical trialprecise genome editingpreclinical trialprogramsrepositoryrepressing CRISPR-dCas9 systemshRNAshort hairpin RNAsiRNAskin barrierskin disordersmall hairpin RNAthree dimensionalthree dimensional cell culturetooltranslation researchtranslational investigationviral gene delivery
Description preview
Genetic modification, such as gene knockdown, overexpression, or precise genome editing, is the most effective
way to elucidate gene function, which has the potential to unveil the mechanisms of skin diseases and advance
therapeutic intervention. The delivery of genetic material into primary skin cells is notoriously difficult and delivery
through…
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