grant
Core B. Genomics and Bioinformatics Core
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 1 Mar 2023Deadline 29 Feb 2028
NIHUS FederalResearch GrantFY2025AffectAntigensArchivesBacteriophagesBasal Transcription FactorBasal transcription factor genesBioinformaticsBioinformatics coreBioinformatics research coreBioinformatics resource coreBovine SpeciesC diffC difficileC. diffC. diff vaccineC. difficileC. difficile vaccineCanine SpeciesCanis familiarisCattleCell BodyCellsClinicalClostridioides difficileClostridioides difficile vaccineClostridium difficileClostridium difficile vaccineCollaborationsComparative StudyDNADNA AlterationDNA ModificationDNA Modification ProcessDNA Sequence AlterationDataDeoxyribonucleic AcidDogsDogs MammalsGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfilingGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGenetic AlterationGenetic DiversityGenetic VariationGenomeGenomicsHumanHybridsImmune responseImmunodeficient MouseImmunologyInfectionIntestinalIntestinesInvestigationMembrane Protein GeneMembrane ProteinsMembrane-Associated ProteinsMessenger RNAMethodsMiceMice MammalsModern ManMurineMusOutcomePhagesPopulationPopulation HeterogeneityProtein AnalysisProteinsRNA SeqRNA sequencingRNA vaccineRNA-based vaccineRNAseqReportingResearch ResourcesResourcesSEQ-ANSamplingSequence AlterationSequence AnalysesSequence AnalysisStatistical Data AnalysesStatistical Data AnalysisStatistical Data InterpretationStructureSurface ProteinsSystemTranscript Expression AnalysesTranscript Expression AnalysisTranscription Factor Proto-OncogeneTranscription factor genesVaccinatedVaccinesVariantVariationWorkanalyze gene expressionarchive dataarchiving databacterial virusbovidbovinebowelcaninecowdata archivedata archivesdata diversitydata managementdesigndesigningdiverse datadiverse populationsdomestic dogfascinatefecal samplegene expression analysisgene expression assaygenomic alterationheterogeneous populationhost responseimmune system responseimmunogenimmunoresponsein vivointerestmRNAmRNA vaccinemRNA-based vaccinemetatranscriptomicsmicrobiomemicrobiome community compositionmicrobiome compositionmicrobiome sequencingmicrobiome species compositionmicrobiome structuremobile DNAmodel organismpopulation diversityprotein structureprotein structuresproteins structureresponsestatistical analysisstatisticsstool samplestool specimentranscription factortranscriptional profilingtranscriptome sequencingtranscriptomic sequencingtransposon/insertion elementvaccine candidatevaccine efficacyvaccines against C . Difficilevaccines against Clostridioides difficile
Description preview
SUMMARY- CORE B (GENOMICS CORE)
Core B (Genomics Core) will provide key support to the mVACS team in Clostridioides difficile genome sequence
analysis, antigen design, microbiome sequence analysis, routine statistical analysis, and high content data
management. Core B will use advanced genomics-based methods to quantify C. difficile genome…
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