grant
Copper homeostasis in fungal pathogenesis
NIHUS FederalResearch GrantFY2026AffectAlveolar MacrophagesAutoregulationBasal Transcription FactorBasal transcription factor genesBindingBioavailabilityBiologic ModelsBiological AvailabilityBiological ModelsBiologyBiometalsBlood CirculationBloodstreamBody TissuesBrainBrain Nervous SystemC neoformansC. neoformansCNS Nervous SystemCell BodyCell ProtectionCell WallCell membraneCell surfaceCellsCellular ExpansionCellular GrowthCentral Nervous SystemCessation of lifeCopperCryptococcus neoformansCu elementCytoplasmic MembraneCytoprotectionDNA mutationDataDeathDefectDetoxification ProcessDevelopmentDiseaseDisorderDrug Metabolic DetoxicationDrug Metabolic DetoxificationEncephalonEnvironmentEnzyme GeneEnzymesEukaryotic CellExposure toFailureFoundationsGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGeneralized GrowthGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationGenetics-MutagenesisGlycansGrowthHIV InfectionsHIV interventionHIV therapeuticHIV therapyHIV treatmentHIV viral infectionHIV virus infectionHIV-1 infectionHIV-1 interventionHIV-1 therapeuticHIV-1 therapyHIV-1 treatmentHealthHomeostasisHumanHuman Immunodeficiency Virus therapyHuman Immunodeficiency Virus treatmentImmuneImmune responseImmune systemImmunesImmunocompromisedImmunocompromised HostImmunocompromised PatientImmunosuppressed HostIn VitroInfectionInfection by HIV-1Infection from HIV-1Infection of HIV-1InflammationInterventionInvadedInvestigatorsIonsLigand BindingLungLung Respiratory SystemMediatingMembraneMetabolic Drug DetoxicationsMetabolism of Toxic AgentsMetalsMicrobeMicrobial PhysiologyModel SystemModelingModern ManMolecular InteractionMutagenesisMutagenesis Molecular BiologyMutationNeuraxisNutrientOrganismPathogenesisPathogenicityPatientsPhagolysosomePhenotypePhysiologicPhysiologic AvailabilityPhysiologicalPhysiological HomeostasisPlasma MembranePolysaccharidesProcessProteinsPulmonary MacrophagesRNA ExpressionRegulationRegulonResearch PersonnelResearchersResistanceRoleSiteStarvationSterolsStressStructureSystemTestingTherapeutic InterventionTissue GrowthTissuesToxic effectToxicitiesTrace ElementsTrace MineralTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTranslatingYeastsbiological adaptation to stresscell growthcofactorcytoprotectivedeprivationdetoxificationdevelopmentalexperienceexperimentexperimental researchexperimental studyexperimentsextracellularfungal pathogenfungi pathogenfungusgenome mutationglobal gene expressionglobal transcription profilehost responsehuman diseasehuman immunodeficiency virus infectionimmune system responseimmunoresponseimmunosuppressed patientin vitro activityin vivoinfected with HIVinfected with human immunodeficiency virusintervention therapyliving systemmembrane structuremicrobe pathogenmicrobialmicrobial pathogenmicroorganismmutantnovelnutrient deprivationnutritional deprivationontogenypathogenpathogenic funguspathogenic microbeplasmalemmaposttranscriptionalreaction; crisisresistantresponsesocial rolestress responsestress; reactiontargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttranscription factortranscriptometreat HIVtreat Human Immunodeficiency Virus
Description preview
SUMMARY
Copper (Cu) is an essential trace element and a catalytic cofactor for a variety of enzymes
involved in cell growth, development, and stress resistance. Fungal systems have been
instrumental in identifying mechanisms of Cu utilization and homeostasis in diverse eukaryotic
cells. The experiments in this proposal will use a relevant fungal…
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