grant
Coordination of DNA Metabolism by Replication Protein A
Organization SAINT LOUIS UNIVERSITYLocation SAINT LOUIS, UNITED STATESPosted 1 May 2023Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY2026AddressAdoptedAffinityAgingAmino AcidsArchitectureBindingBiochemicalBiophysicsCancer CauseCancer EtiologyCell BodyCellsChromosomal RearrangementComplexDNADNA BindingDNA Binding DomainDNA Binding InteractionDNA Damage RepairDNA MaintenanceDNA RecombinationDNA RepairDNA Repair PathwayDNA ReplicationDNA StabilityDNA SynthesisDNA biosynthesisDNA boundDNA damage check pointDNA damage check point responseDNA damage checkpointDNA damage checkpoint responseDNA metabolismDNA replication factor ADNA-Binding Protein MotifsDefectDeoxyribonucleic AcidDissociationDouble-Stranded DNAEngineering / ArchitectureEnzyme GeneEnzymesFluorescenceGatekeepingGeneticGenetic RecombinationGenomeGenome StabilityGenomic StabilityGoalsHereditary DiseaseInborn Genetic DiseasesIndividualInherited disorderIntermediary MetabolismInvestigationKineticsKnowledgeLabelLeadLengthMetabolicMetabolic ProcessesMetabolismModelingMolecularMolecular InteractionNucleosomesPathway interactionsPb elementPhosphorylationPositionPositioning AttributePost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingProcessPropertyProtein ModificationProtein PhosphorylationProteinsRecombinationReplication ProcessReplication-Associated ProcessRoleSingle-Stranded DNASiteSpecificityTelomere MaintenanceTherapeuticThermodynamicThermodynamicsUnscheduled DNA SynthesisWorkaminoacidbiophysical equipmentbiophysical foundationbiophysical principlesbiophysical sciencesbiophysical toolsdexterityds-DNAdsDNAflexibilityflexiblegatekeepergenome integritygenomic integrityheavy metal Pbheavy metal leadhereditary disorderheritable disorderinborn errorinherited diseasesinherited genetic diseaseinherited genetic disordernovelpathwayprotein functionrecruitrepairrepairedreplication factor Areplication protein Asingle-strand binding protein RP-Asocial rolessDNAtelomeretool
Description preview
Summary
DNA metabolic processes including replication, repair, recombination, and telomere maintenance occur on
single-stranded DNA (ssDNA). In each of these complex processes, dozens of proteins function together on the
ssDNA template. However, when double-stranded DNA is unwound, the transiently open ssDNA is protected
and coated by the high…
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