grant
Coordinated responses to host-derived stresses in C. neoformans
NIHUS FederalResearch GrantFY2025AIDSAPF-1ATP-Dependent Proteolysis Factor 1Acquired Immune DeficiencyAcquired Immune Deficiency SyndromeAcquired Immunodeficiency SyndromeAddressApplications GrantsArrestinsBasidiomycetesBasidiomycotaBiochemicalBlood Plasma CellC neoformansC. neoformansCancer TreatmentCapsulesCell BodyCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCell WallCell membraneCell surfaceCellsCellular FunctionCellular PhysiologyCellular ProcessCellular StressCellular Stress ResponseCessation of lifeCollectionComplexCryptococcus neoformansCytoplasmic MembraneDataDeathDiseaseDisorderDrug ToleranceE3 LigaseE3 Ubiquitin LigaseEnvironmentEukaryotic CellEventFungus DiseasesFutureGeneticGenetic ScreeningGenetic TechnicsGenetic TechniquesGoalsGrafting ProcedureGrant ProposalsHMG-20High Mobility Protein 20HumanImmuneImmune responseImmune systemImmunesImpairmentIn VitroInfectionInterventionIntracellular Communication and SignalingInvestigatorsMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMediatingMicrobeMicrobial GeneticsModelingModern ManMolecularMycosesNutrient availabilityOrgan TransplantationOrgan TransplantsPathogenesisPathogenicityPathway interactionsPatientsPhenotypePhosphorylationPlasma CellsPlasma MembranePlasmacytesPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingPreventionProcessProtein ModificationProtein PhosphorylationProteinsProteomicsRegulationResearch PersonnelResearchersRetinal S-AntigenRiskScience of Microbial GeneticsSignal PathwaySignal TransductionSignal Transduction SystemsSignalingStressSubcellular ProcessSurfaceSystemTestingTherapeutic FungicidesUbiquitilationUbiquitinUbiquitin Ligase Component GeneUbiquitin Ligase GeneUbiquitin Protein LigaseUbiquitin-Protein Ligase ComplexesUbiquitin-Protein Ligase E3UbiquitinationUbiquitinoylationVariantVariationVirulenceanti-cancer therapyanti-fungalanti-fungal agentsanti-fungal druganti-microbialantimicrobialbiological signal transductioncancer therapycancer-directed therapycapsulecell stresscomparativeexperimentexperimental researchexperimental studyexperimentsextracellularfitnessfungal infectionfungal pathogenfungi pathogenfungusfungus infectiongene manipulationgenetic manipulationgenetically manipulategenetically perturbhost responseimmune system responseimmunoresponsein vivoin vivo Modelinfectious disease treatmentmicrobe pathogenmicrobialmicrobial hostmicrobial pathogenmicroorganismmicroorganism geneticsmutantnovelopportunistic pathogenoptimal therapiesoptimal treatmentsorgan allograftorgan graftorgan xenograftpathogenic funguspathogenic microbepathwaypharmacologicplasmalemmaplasmocyteresponsescaffoldscaffoldingscreeningscreeningssensortraffickingtranscriptomicsubiquinationubiquitin conjugationubiquitin ligaseubiquitin-protein ligase
Description preview
SUMMARY
Although potent antifungal agents are currently available, invasive fungal infections remain
highly prevalent causes of disease and death, especially in our most vulnerable patients with defective
immune systems. AIDS, organ transplantation, and more aggressive cancer treatments all contribute to
ever-expanding patient groups who are at…
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