grant
Coordinated Control of Metabolism by Enzymes and Transporters
Organization BROWN UNIVERSITYLocation PROVIDENCE, UNITED STATESPosted 1 Sept 2025Deadline 30 Jun 2030
NIHUS FederalResearch GrantFY20253-PyridinecarboxamideADP Ribose TransferasesADP-RibosyltransferaseADPRTsART TransferasesARTasesAccelerationAddressAgingAnabolismAutoregulationBasic ResearchBasic ScienceBiochemical ReactionBiologicalBiologyBody TissuesCardiovascular DiseasesCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCell membraneCellular FunctionCellular PhysiologyCellular ProcessCirculationClinical TrialsConsumptionCyclic ADP-RiboseCyclic ADPriboseCyclic Adenosine Diphosphate RiboseCytoplasmic MembraneDegenerative Neurologic DisordersDiabetes MellitusDihydronicotinamide Adenine DinucleotideDiphosphopyridine NucleotideDiseaseDisorderDoctor of PhilosophyEffectivenessEnzymatic ReactionEnzyme GeneEnzyme InteractionEnzymesEquilibriumGI microbiomeGeneticGenomeGoalsHomeostasisHumanIntermediary MetabolismIntracellular Communication and SignalingIonsMammaliaMammalian CellMammalsMetabolicMetabolic PathwayMetabolic ProcessesMetabolismMicrobiomicsModern ManNadideNervous System Degenerative DiseasesNeural Degenerative DiseasesNeural degenerative DisordersNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNiacinamideNicotinamideNicotinamide adenine dinucleotideNicotinamide-Adenine DinucleotideNicotinamidumNicotinic acid amideNicotylamideNutrientObesityOxidation-ReductionPathway interactionsPellagra-Preventing FactorPh.D.PhDPhasePhysiological HomeostasisPlasma MembraneProcessRedoxRegulationResearchRodent DiseasesSignal TransductionSignal Transduction SystemsSignalingSilent Mating Type Information Regulator 2-like ProteinsSir2-like ProteinsSirtuinsSiteSubcellular ProcessSupplementationSystemSystems BiologyTissuesTransferaseTransferase GeneTranslational ResearchTranslational ScienceUniversitiesVitamin B 3Vitamin B3Vitamin PPWorkadipositybalancebalance functionbiologicbiological signal transductionbiosynthesiscADP-RibosecADPRcardiovascular disordercatalystcofactorcorpulencedegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdiabetesdigestive tract microbiomedisease modeldisorder modelenteric microbiomegastrointestinal microbiomegut microbiomegut-associated microbiomeintestinal biomeintestinal microbiomemicrobiome researchmicrobiome sciencemicrobiome studiesneurodegenerative illnessnoveloxidation reduction reactionpathwaypharmacologicplasmalemmaprogramstooltranslation researchtranslational investigationuptake
Description preview
Karthikeyani Chellappa PhD, Brown University
Coordinated Control of Metabolism by Transporters and Enzymes
The transport of molecules across the plasma membrane is a highly regulated process that impacts metabolism at
subcellular to organismal scales. The physical association of enzymes in a pathway or the association of
transporters and enzymes…
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