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Controlling complement to unleash nanomedicine for acute critical illnesses
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 1 Feb 2022Deadline 31 Jan 2026 ⚠️
NIHUS FederalResearch GrantFY20259-Octadecenoic AcidARDSAcuteAcute Respiratory DistressAcute Respiratory Distress SyndromeAdoptedAdult ARDSAdult RDSAdult Respiratory Distress SyndromeAffectAir BladderAir SacsAllelism TestAlveolarAlveolusAmino Acid MotifsAnaphylactic ReactionAnaphylactic ShockAnaphylaxisAntibodiesApoplexyArtificial nano particlesArtificial nanoparticlesAssayBindingBinding ProteinsBioassayBiological AssayBloodBlood NeutrophilBlood PlasmaBlood Polymorphonuclear NeutrophilBlood ProteinsBlood Reticuloendothelial SystemBlood SerumBlood capillariesBlood leukocyteBrain Vascular AccidentBronchial AlveolusC3 aC3 regulatorC3aC3biCOVID-19COVID-19 associated deathCOVID-19 associated fatalityCOVID-19 associated mortalityCOVID-19 deathCOVID-19 fatalityCOVID-19 induced deathCOVID-19 induced fatalityCOVID-19 induced mortalityCOVID-19 mortalityCOVID-19 related deathCOVID-19 related fatalityCOVID-19 related mortalityCOVID19 associated deathCOVID19 associated fatalityCOVID19 associated mortalityCOVID19 deathCOVID19 fatalityCOVID19 induced deathCOVID19 induced fatalityCOVID19 induced mortalityCOVID19 mortalityCOVID19 related deathCOVID19 related fatalityCOVID19 related mortalityCR3CR3 ReceptorCV-19CancersCardiac infarctionCause of DeathCell BodyCellsCerebral StrokeCerebrovascular ApoplexyCerebrovascular StrokeCessation of lifeClinical Treatment MoabComplementComplement 3 ReceptorComplement 3aComplement ActivationComplement C3aComplement Factor HComplement Factor PComplement ProteinsComplementation TestCoronavirus Infectious Disease 2019Critical CareCritical IllnessCritically IllDa Nang LungDeathDiseaseDisorderDrug CarriersDrug DeliveryDrug Delivery SystemsDrugsDysfunctionEndothelial CellsEndotheliumEngineeringFactor HFunctional disorderGenetic Complementation TestHumanHypotensionImmuneImmunesIn VitroInflammatoryInjectionsIntegrin alpha-M beta-2Integrin alphaMbeta2Knock-outKnockoutLeadLeukocytesLeukocytes Reticuloendothelial SystemLifeLigand Binding ProteinLigand Binding Protein GeneLigandsLiposomalLiposomesLow Blood PressureLungLung InflammationLung Respiratory SystemLung damageMac 1Mac-1 Adhesive ReceptorMac-1 AntigenMac-1 ReceptorMacrophage-1 AntigenMalignant NeoplasmsMalignant TumorMarrow NeutrophilMarrow leukocyteMeasuresMedicationMembrane Protein GeneMembrane ProteinsMembrane-Associated ProteinsMiceMice MammalsMicrobeMo1 Antigen ReceptorMo1 Glycoprotein ReceptorModelingModern ManMolecular InteractionMonoclonal AntibodiesMurineMusMyocardial InfarctMyocardial InfarctionNanotechnologyNebulizerNeutrophilic GranulocyteNeutrophilic LeukocyteOleic AcidsOrganOut-patientsOutcomeOutpatientsPatientsPb elementPerfusionPharmaceutical PreparationsPhenotypePhysiciansPhysiopathologyPlasmaPlasma ProteinsPlasma SerumPlayPneumonitisPolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsProperdinProtein BindingProtein MotifsPulmonary InflammationReactionReceptor ProteinRecombinantsReportingReticuloendothelial System, Serum, PlasmaRoleSARS-CoV-2 associated deathSARS-CoV-2 associated fatalitySARS-CoV-2 associated mortalitySARS-CoV-2 deathSARS-CoV-2 fatalitySARS-CoV-2 induced deathSARS-CoV-2 induced fatalitySARS-CoV-2 induced mortalitySARS-CoV-2 mortalitySARS-CoV-2 related deathSARS-CoV-2 related fatalitySARS-CoV-2 related mortalitySepsisSerumShock LungSideSpleenSpleen Reticuloendothelial SystemStiff lungStrokeSurface ProteinsSwimbladderTechnologyTestingTherapeuticTherapeutic EffectTrans TestVascular Hypotensive DisorderWhite Blood CellsWhite CellWild Type MouseWorkantibody conjugatebound proteinbrain attackcapillarycardiac infarctcerebral vascular accidentcerebrovascular accidentcis-9-Octadecenoic Acidclinical translationclinically translatablecomplement 3 regulatorcomplement pathwaycomplement pathway regulationcomplementationcomplementation analysiscomplementation approachcoronary attackcoronary infarctcoronary infarctioncoronavirus disease 2019coronavirus disease 2019 associated deathcoronavirus disease 2019 associated fatalitycoronavirus disease 2019 associated mortalitycoronavirus disease 2019 deathcoronavirus disease 2019 fatalitycoronavirus disease 2019 induced deathcoronavirus disease 2019 induced fatalitycoronavirus disease 2019 induced mortalitycoronavirus disease 2019 mortalitycoronavirus disease 2019 related deathcoronavirus disease 2019 related fatalitycoronavirus disease 2019 related mortalitycoronavirus disease-19coronavirus disease-19 mortalitycoronavirus infectious disease-19cytokinedeath due to COVID-19death due to COVID19death due to SARS-CoV-2death due to coronavirus disease 2019death due to severe acute respiratory syndrome coronavirus 2death in COVIDdeath in COVID-19death in SARS-CoV-2death in coronavirus diseasedeath in coronavirus disease 2019death in severe acute respiratory syndrome coronavirus 2densitydesigndesigningdrug/agentengineered nano particleengineered nanoparticleex vivo perfusionexperimentexperimental researchexperimental studyexperimentsfactor Pfatality due to COVID-19fatality due to COVID19fatality due to SARS-CoV-2fatality due to coronavirus disease 2019fatality due to severe acute respiratory syndrome coronavirus 2heart attackheart infarctheart infarctionheavy metal Pbheavy metal leadhuman tissueiC3bimprovedin vitro testingin vivoinhibitorlung injurymAbsmalignancymigrationmonoclonal Absmortality due to COVID-19mortality due to COVID19mortality due to SARS-CoV-2mortality due to coronavirus disease 2019mortality due to severe acute respiratory syndrome coronavirus 2mouse modelmurine modelnano medicinalnano medicinenano particlenano technano technologynano-sized particlenano-technologicalnanocarriernanomedicinalnanomedicinenanoparticlenanosized particlenanotechnanotechnologicalnanovesselnebulizationnebulizeneoplasm/cancerneutralizing antibodyneutrophilpathophysiologypreventpreventingpulmonarypulmonary damagepulmonary injurypulmonary tissue damagepulmonary tissue injuryreceptorsevere acute respiratory syndrome coronavirus 2 associated deathsevere acute respiratory syndrome coronavirus 2 associated fatalitysevere acute respiratory syndrome coronavirus 2 associated mortalitysevere acute respiratory syndrome coronavirus 2 deathsevere acute respiratory syndrome coronavirus 2 fatalitysevere acute respiratory syndrome coronavirus 2 induced deathsevere acute respiratory syndrome coronavirus 2 induced fatalitysevere acute respiratory syndrome coronavirus 2 induced mortalitysevere acute respiratory syndrome coronavirus 2 mortalitysevere acute respiratory syndrome coronavirus 2 related deathsevere acute respiratory syndrome coronavirus 2 related fatalitysevere acute respiratory syndrome coronavirus 2 related mortalityside effectsocial rolestandard measurestrokedstrokestissue resourcetranslational opportunitiestranslational potentialuptakewet lungwhite blood cellwhite blood corpusclewildtype mouseαMβ2
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ABSTRACT / SUMMARY
Acute critical illnesses rapidly lead to severe organ damage and loss of life. These illnesses include
sepsis, stroke, and acute respiratory distress syndrome (ARDS). Here we focus on ARDS, which is acute
inflammation of the lungs’ air sacs, and the cause of death in COVID-19. For ARDS and these other diseases,
we have…
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