grant
Contributions of prion strains and substrains to prion zoonotic potential and evolution
NIHUS FederalResearch GrantFY2025AbscissionAnimalsAssayBioassayBiochemicalBiological AssayChronic Wasting DiseaseCricetinaeDNA mutationDataDevelopmentDigestionDiseaseDisorderDrowsinessDrug resistanceDrugsEncephalopathiesEnvironmentEsteroproteasesEvaluationEvolutionExcisionExtirpationFrequenciesGenerationsGenetic ChangeGenetic defectGenetic mutationGenotypeGoalsHamstersHamsters MammalsHumanIn VitroMedicationMethodsMiceMice MammalsMinkModelingModern ManMolecular ConfigurationMolecular ConformationMolecular StereochemistryMurineMusMutationPRNPPathogenicityPeptidasesPeptide HydrolasesPharmaceutical PreparationsPrPPrP ProteinsPrP genePrPScPrPSc ProteinsPrion ProteinsPrion protein genePrionsProceduresProductionPropertyProtease GeneProteasesProteinasesProteinsProteolytic EnzymesRemovalRoleScrapie AgentScrapie PrPSomnolenceSurgical RemovalTestingTransmissionVaccinationWorkZoonosesZoonoticZoonotic Infectioncervidcommunicable disease transmissionconformationconformationalconformational stateconformationallyconformationscross-species spillovercross-species transmissiondetection methoddetection proceduredetection techniquedevelopmentaldisease transmissiondisease-associated PrPdrug resistantdrug/agentgenome mutationhost jumphost switchingin vivoinfectious disease transmissioninterspecies transmissionpreventpreventingprion-likeresectionresistance strainresistance to Drugresistant strainresistant to Drugsleepinesssocial rolethermolabilitythermostabilitytransmission across speciestransmission between speciestransmission processtransmitted across speciestransmitted between speciestransmitted cross-species
Description preview
Prions are infectious protein-only zoonotic agents that can rapidly evolve in a new replication environment.
Prion strains are encoded by strain-specific conformations of PrPSc, the infectious form of the host-encoded
prion protein, PrPC. Collinge and Clarke hypothesized that prion strains are a mixture of a dominant prion strain
and substrains.…
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