grant
Contributions of Ebola and Marburg virus VP30 and VP24 proteins to viral RNA synthesis, assembly and egress
Organization WASHINGTON UNIVERSITYLocation SAINT LOUIS, UNITED STATESPosted 7 Jul 2016Deadline 31 May 2028
NIHUS FederalResearch GrantFY2025AddressAffectAntioxidantsAssayBasal Transcription FactorBasal transcription factor genesBindingBioassayBiological AssayBiophysicsCDC42 Homolog GeneCDC42-Interacting Protein GeneCIP4CRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCas nuclease technologyCell BodyCell Communication and SignalingCell ProtectionCell SignalingCellsClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyContainmentCytoprotectionDNA mutationDataDependenceDiseaseDisorderEBOVEbola virusEbola-like VirusesExhibitsFamilyFiloviridaeFilovirusFrankfurt-Marburg Syndrome VirusG25K GeneGP GeneGene TranscriptionGeneHomologGeneral Transcription Factor GeneGeneral Transcription FactorsGeneralized GrowthGenesGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationGoalsGrowthHomologHomologous GeneHomologueHost FactorHost Factor ProteinIFNImportin-alphaImportin-αInfectionIntegration Host FactorsInterferonsIntracellular Communication and SignalingKnock-outKnockoutKnowledgeLengthMGLAPMGP geneMarburgMarburg virusMarburg-like VirusesMarburgvirusMediatingModelingModificationMolecularMolecular InteractionMutationNLS ReceptorNLS-Binding ProteinNLSBPNon-Polyadenylated RNANuclear FamilyNuclear ImportNuclear Localization Sequence ReceptorNuclear Localization Signal-Binding ProteinNucleocapsidNucleoproteinsOrthoebolavirusOrthomarburgvirusOutcomePathogenesisPathway interactionsPeptidesPlayProductionPropertyProtein TruncationProteinsR-Series Research ProjectsR01 MechanismR01 ProgramRNARNA ExpressionRNA Gene ProductsRNA ProcessingRNA analysisRNA and protein interactionRNA chemical synthesisRNA synthesisRNA-Protein InteractionRecombinantsRegulationReportingResearch GrantsResearch Project GrantsResearch ProjectsRibonucleic AcidRoleShort interfering RNASignal TransductionSignal Transduction SystemsSignalingSmall Interfering RNAStructureSystemTRIP10TRIP10 geneTestingThyroid Hormone Receptor Interactor 10 GeneTissue GrowthTranscriptionTranscription Factor Proto-OncogeneTranscription InitiationTranscription Initiation SiteTranscription Start SiteTranscription factor genesTranscriptional ControlTranscriptional RegulationTransfectionViralViral DiseasesViral Structural ProteinsVirionVirusVirus DiseasesVirus ParticleVirus ReplicationVirus-like particleWorkalpha Karyopherinsbiological signal transductionbiophysical foundationbiophysical principlesbiophysical sciencescytoprotectiveemergent virusemerging virusgenome mutationmembermutantnovelontogenyoverexpressoverexpressionpathwayrecombinant virusresponsesiRNAsocial rolestemsuccesstooltranscription factorviral RNAviral emergenceviral infectionviral multiplicationviral replicationvirus RNAvirus infectionvirus multiplicationvirus-induced diseasevirus-like nanoparticlesviruslike particle
Description preview
RP02 Project Summary/Abstract for Contributions of Ebola and Marburg virus VP30 and VP24 proteins
to viral RNA synthesis, assembly and egress
Marburg virus (MARV) and Ebola virus (EBOV) are deadly emerging viruses of the filovirus family. Major gaps
remain in our understanding as to how filoviral-filoviral and filoviral-host interactions promote…
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