grant
Contribution of antibodies targeting PLP1-anchored membrane domains to multiple sclerosis pathogenesis
Organization UNIVERSITY OF COLORADO DENVERLocation Aurora, UNITED STATESPosted 5 Sept 2024Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY202521+ years old7S Gamma GlobulinAb responseAddressAdultAdult HumanAntibodiesAntibody FormationAntibody ProductionAntigen PresentationAntigen TargetingAntigenic DeterminantsAntigensAssayAstrocytesAstrocytusAstrogliaAutopsyB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellBindingBinding DeterminantsBinding ProteinsBioassayBiological AssayBiopsy SampleBiopsy SpecimenBlood SerumBody TissuesBrainBrain Nervous SystemC 5b-9C5b-9CD68 antigenCNS DiseasesCNS InjuryCNS Nervous SystemCNS disorderCausalityCd68Cell BodyCell DeathCell Membrane LipidsCellsCentral Nervous SystemCentral Nervous System DiseasesCentral Nervous System DisordersCerebrospinal FluidChildhoodCholesterolClinicalClinical DataClone CellsComplementComplement Complex C5b-9Complement Membrane Attack ComplexComplement ProteinsComplement-Dependent CytotoxicityComplexCytolytic Terminal Complement ComplexDataDemyelinationsDepositDepositionDiagnosisDiseaseDisorderDisseminated SclerosisDocumentationDysfunctionELISAEarly treatmentEncephalonEnzyme-Linked Immunosorbent AssayEpitopesEtiologyFe elementFolch-Lees ProteinFolch-PI Proteolipid ProteinFunctional disorderGalactocerebrosidesGalactosyl CeramidesGalactosylceramidesGene TargetingGlycolipidsGoalsHistopathologyHistoryHumanIgGIgG1Immune PrecipitationImmune responseImmunoassayImmunochemical ImmunologicImmunochemistryImmunoglobulin GImmunologicImmunologicalImmunologicallyImmunologicsImmunoprecipitationIndividualInfiltrationInflammatoryIronKO miceKnock-out MiceKnockout MiceLesionLigand Binding ProteinLigand Binding Protein GeneLinkMR ImagingMR TomographyMRIMRIsMS LesionsMS patientMagnetic Resonance ImagingMeasurableMediatingMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMembraneMembrane Attack ComplexMembrane LipidsMembrane Protein GeneMembrane ProteinsMembrane-Associated ProteinsMiceMice MammalsMicroinjectionsModelingModern ManMolecularMolecular ConfigurationMolecular ConformationMolecular InteractionMolecular StereochemistryMultiple SclerosisMultiple Sclerosis LesionsMurineMusMyelinMyelin PLPMyelin ProteinsMyelin Proteolipid ProteinNMR ImagingNMR TomographyNatureNerve CellsNerve UnitNervous System DiseasesNervous System DisorderNervous System controlNeural CellNeuraxisNeurocyteNeurologicNeurologic DisordersNeurologicalNeurological DisordersNeurological disabilityNeuronsNuclear Magnetic Resonance ImagingNull MouseOligoclonal BandsOligoclonal IgGOligoclonal ImmunoglobulinsOligodendrocytesOligodendrocytusOligodendrogliaOligodendroglia CellPathogenesisPathogenicityPathologyPatient CarePatient Care DeliveryPatientsPhagocytesPhagocytic CellPhasePhysiopathologyPlasmablastPlayPrevalenceProcessPrognosisPrognostic MarkerProtein BindingProteinsProteolipidsProtocolProtocols documentationRecombinant AntibodyRecombinantsRecording of previous eventsRelapseResearch SpecimenRoleSamplingSensitivity and SpecificitySerumSeverity of illnessSliceSolidSpecificitySpecimenSulfatidesSulfatoglycosphingolipidsSulfoglycosphingolipidsSurface ProteinsSyndromeT-CellsT-LymphocyteTerminal Complement ComplexTestingTherapeuticTimeTissuesTransfectionTransgenic OrganismsZeugmatographyaccurate diagnosisadulthoodamebocyteantibody biosynthesisastrocytic gliabiobankbiorepositorybound proteincare for patientscare of patientscaring for patientscausationcentral nervous system demyelinating diseasecentral nervous system demyelinating disordercentral nervous system injurycerebral spinal fluidcomplement-mediated cytotoxicitycomplementationconformationconformationalconformational stateconformationallyconformationscytokinedemographicsdemyelinatediagnostic biomarkerdiagnostic criteriadiagnostic markerdisabilitydisease causationdisease controldisease severitydisorder controlearly therapyenzyme linked immunoassayhistorieshost responseimmune system responseimmunogenimmunoglobulin biosynthesisimmunoresponseimprovedin vivoin vivo Modelinjured CNSinsular sclerosismembrane structuremultiple sclerosis patientmyelin proteolipidnecrocytosisnecropsyneurological diseaseneuronalnew markernovelnovel biomarkernovel markerpathogenpathogenic autoantibodiespathophysiologypatients with MSpatients with multiple sclerosispediatricpeople with Multiple sclerosispostmortemprognostic biomarkerprognostic indicatorprotein complexrapid diagnosisre-myelinatere-myelinationremyelinateremyelinationrepairrepairedresponseresponse to therapyresponse to treatmentsocial rolespecific biomarkersspinal fluidsubstantia albatherapeutic biomarkertherapeutic markertherapeutic responsetherapy responsethymus derived lymphocytetime usetissue/cell culturetransgenictreatment responsetreatment responsivenesswhite matter
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Project Summary
A role for B-cells in multiple sclerosis (MS) pathogenesis has been implicated by clinical, histopathologic and
immunologic studies. The precise role they play in pathology is debated and impact could be mediated through
antibody (Ab) production, secretion of pro-inflammatory cytokines, or antigen presentation to T cells. To study…
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