grant

Connectivity and function of inhibitory neurons in the primate visual cortex

Organization UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAHLocation SALT LAKE CITY, UNITED STATESPosted 30 Sept 2020Deadline 31 Mar 2031
NIHUS FederalResearch GrantFY2026AD dementiaAddressAffectAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimers DementiaAnatomic SitesAnatomic structuresAnatomyAnimalsBehavioralBiologic ModelsBiological ModelsBrainBrain Nervous SystemCCRL2CCRL2 geneCKRXCRAM-ACRAM-BCRE RecombinaseCallithrixCell BodyCellsCerebral cortexChemicalsChemokine (C-C Motif) Receptor-Like 2 GeneColorComputer ModelsComputerized ModelsConnectionist ModelsCyclic SomatostatinDataDevelopmentDysfunctionElectrophysiologyElectrophysiology (science)EncephalonEnhancersEnterobacteria phage P1 Cre recombinaseEpilepsyEpileptic SeizuresEpilepticsExpression SignatureFoundationsFunctional disorderGene ExpressionGene Expression ProfileGlutamatesGoalsGrantGrowth Hormone Inhibiting FactorsGrowth Hormone-Inhibiting HormoneHCRHapaleHumanImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodKnowledgeL-GlutamateLabelLogicMapsMarmosetsMeasuresMediatingMental disordersMental health disordersMiceMice MammalsMigraineMigraine HeadacheModel SystemModelingModern ManMolecularMorphologyMurineMusNeocortexNerve CellsNerve UnitNervous System DiseasesNervous System DisorderNeural CellNeural Network ModelsNeural Network SimulationNeurocyteNeurologic DisordersNeurological DisordersNeuronal DysfunctionNeuronsNeurophysiology / ElectrophysiologyPHM27ParvalbuminsPatternPerceptronsPhysiopathologyPrimary Senile Degenerative DementiaPrimary visual cortexPrimatesPrimates MammalsPropertyPsychiatric DiseasePsychiatric DisorderRabies lyssavirusRabies mappingRabies trans synaptic tracingRabies virusRabies virus mediated mappingRecurrenceRecurrentResearchRoleSRIHSRIH-14SchizophreniaSchizophrenic DisordersSeizure DisorderSensoryShapesShort-Tusked MarmosetSomatostatinSomatostatin-14Somatotropin Release Inhibiting FactorsSomatotropin Release-Inhibiting HormoneSourceSpecificityStriate CortexStriate areaStructureTechnologyTestingTimeTransgenesTranslatingVasoactive Intestinal PeptideVasoactive Intestinal PolypeptideVasointestinal PeptideViralVisualVisual Cortexabnormal brain functionarea striatabacteriophage P1 recombinase Crebiomarker identificationbrain dysfunctionbrain impairmentcell typecomputational modelingcomputational modelscomputer based modelscomputerized modelingdementia praecoxdevelopmentaldysfunctional brainelectrophysiologicalepilepsiaepileptogenicexperimentexperimental researchexperimental studyexperimentsextrastriate areaextrastriate cortexextrastriate visual cortexgene expression patterngene expression signatureglutamatergicgrowth hormone release inhibiting factorhomotypical cortexidentification of biomarkersidentification of new biomarkersinhibitory neuroninsightisocortexmarker identificationmental illnessmolecular biomarkermolecular markerneopalliumneuralneural circuitneural circuitryneural dysfunctionneurocircuitryneurological diseaseneuronalnon-human primatenonhuman primatenoveloptic imagingoptical imagingoptogeneticspathophysiologyprimary degenerative dementiapromoterpromotorpsychiatric illnesspsychological disorderrabies based mappingrabies based retrograde mappingrabies circuit tracingrabies mediated retrograde monosynaptic tracingrabies retrograde tracingrabies tracerrabies tracingrabies viral tracingrabies virus mediated circuit mappingrabies virus monosynaptic circuit tracingrabies virus monosynaptic tracingrabies virus neurotracerrabies virus retrograde tracingrabies virus tracingresponseschizophrenicselective expressionselectively expressedsenile dementia of the Alzheimer typesocial rolespatial and temporalspatial temporalspatiotemporalsynaptic circuitsynaptic circuitrytooltracing with rabiestranscriptional profiletranscriptional signaturetranscriptomicstransgenevectorvisual areavisual cortical
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PROJECT SUMMARY
In the mammalian neocortex, cortical computations result from the activity of neural circuits composed mainly

of glutamatergic excitatory and GABAergic inhibitory neurons (INs). INs profoundly influence cortical

computations and dynamics, via a diversity of types, with distinct morphological, electrophysiological, and

molecular…

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