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Compressed sequential infection regimen to model immune responses to systemic and mucosal vaccination
Organization WASHINGTON UNIVERSITYLocation SAINT LOUIS, UNITED STATESPosted 1 Feb 2024Deadline 31 Dec 2025 ⚠️
NIHUS FederalResearch GrantFY20252019-nCoV vaccine21+ years oldAdenoviridaeAdenovirusesAdultAdult HumanAgeAntibiotic TherapyAntibiotic TreatmentAntibodiesAntibody ResponseAssayAstrovirusBedsBioassayBiological AssayBlood SerumBlood granulocytic cellCOVID-19 vaccinationCOVID-19 vaccineCell BodyCellsClinical TrialsCommunicable DiseasesCommunitiesContainmentControlled EnvironmentDataDevelopmentDisadvantagedDrugsEnteralEntericEnterovirusEnvironmentExhibitsExposure toGerm-FreeGoalsGranular LeukocytesGranulocytic cellHelminthsHerpesviridaeHerpesvirusesHistoryHousingHumanImmuneImmune Cell ActivationImmune responseImmune systemImmunesImmunityImmunologic ModelImmunologic StimulationImmunologic SubtypingImmunological ModelsImmunological StimulationImmunophenotypingImmunostimulationIndividualInfectionInfectious DiseasesInfectious DisorderInflammatoryInfluenza VirusInterventionIntestinalIntestinesIntramuscularInvestigatorsLaboratory miceLifeLymphatic cellLymphocyteLymphocyticMedicationMethodsMiceMice MammalsMicrobeModelingModern ManMucosaMucosal TissueMucous MembraneMurineMusNorovirusNorwalk-like VirusesOutcomeParasitic WormsPharmaceutical PreparationsPhenotypePredictive ValueProtocolProtocols documentationPublishingRecording of previous eventsRegimenResearchResearch PersonnelResearchersRiskRoleRotavirusSARS-CoV-2 vaccinationSARS-CoV-2 vaccineSARS-coronavirus-2 vaccineSeriesSerumSevere Acute Respiratory Syndrome CoV 2 vaccineSevere acute respiratory syndrome coronavirus 2 vaccinationSevere acute respiratory syndrome coronavirus 2 vaccineTestingVaccinationViralViral DiseasesVirus DiseasesWeaningWorkadulthoodagesanimal facilityartificial environmentbacterial disease treatmentbacterial infectious disease treatmentbacterial microbiomebacteriomebowelcommunity microbescoronavirus disease 2019 vaccinationcoronavirus disease 2019 vaccinecoronavirus disease-19 vaccinecostcytokinedevelopmentaldrug/agentevaluate vaccinesexperienceexperimentexperimental researchexperimental studyexperimentsfecal microbial transplantationfecal microbiome transplantationfecal microbiota transplantfecal microbiota transplantationfecal transplantfecal transplantationfetalfungal microbiomegranulocyteherpes virushistorieshost responsehuman modelimmune activationimmune system responseimmunoresponsein vivoinfluenzavirusinsightlymph cellmicrobe communitymicrobialmicrobial communitymicrobial consortiamicrobial floramicrobiomemicrobiotamicrobiota communitymicrobiota compositionmicrofloramicroorganism communitymodel of humanmouse modelmucosal vaccinationmucosal vaccinemultispecies consortiamurine modelmycobiomenCoV vaccinenCoV-19 vaccinenCoV19 vaccineneonatal micenovelpathogenpathogen exposurepathogenic viruspolymicrobial communitypreservationresponsesocial roletoolvaccinate against COVID-19vaccinate against SARS-CoV-2vaccinate against coronavirus disease 2019vaccinate against severe acute respiratory syndrome coronavirus 2vaccination against COVID-19vaccination against SARS-CoV-2vaccination against Severe acute respiratory syndrome coronavirus 2vaccination against coronavirus disease 2019vaccine against 2019-nCovvaccine against COVID-19vaccine against SARS-CoV-2vaccine against SARS-coronavirus-2vaccine against Severe Acute Respiratory Syndrome CoV 2vaccine against Severe acute respiratory syndrome coronavirus 2vaccine candidates against SARS-CoV-2vaccine evaluationvaccine for novel coronavirusvaccine responsevaccine responsivenessvaccine screeningvaccine testingvaccine-induced responsevaccines preventing COVIDvaccines to prevent COVIDviral infectionviral microbiomeviral pathogenviromevirus infectionvirus pathogenvirus-induced disease
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Description preview
PROJECT SUMMARY/ABSTRACT
Laboratory mice exhibit underdeveloped immune systems which fail to accurately predict human
responses to challenges such as vaccination. Intentional exposure of these mice to environmental microbes
(creating “dirty” mice) through various approaches has been shown to confer effective maturation of the immune
system, but…
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