grant
Comprehensively mapping the functional and antigenic effects of mutations to the Lassa virus glycoprotein complex
Organization UNIVERSITY OF WASHINGTONLocation SEATTLE, UNITED STATESPosted 1 Aug 2025Deadline 31 Dec 2028
NIHUS FederalResearch GrantFY2025AffectAmino AcidsAntibodiesAntibody ResponseAntibody SpecificityAntibody TherapyAntigensCell BodyCellsCessation of lifeClinical Treatment MoabComplexDNA mutationDataDeathDevelopmentEvolutionFutureGenetic ChangeGenetic defectGenetic mutationGlycoproteinsHumanHumoral ImmunitiesImmune responseInfectionInvestigatorsLassaLassa FeverLassa diseaseLassa fever virusLassa virusLentivirinaeLentivirusLibrariesMapsMastomysMeasurementMeasuresMediatingMembrane Protein GeneMembrane ProteinsMembrane-Associated ProteinsModern ManMonoclonal AntibodiesMutationPersonsPhylogenetic AnalysisPhylogeneticsProtein RegionProteinsResearch PersonnelResearchersRiskRodentRodentiaRodents MammalsSpecificitySurface ProteinsTherapeuticTherapeutic antibodiesTreesVaccinesVariantVariationViralViral DiseasesVirusVirus DiseasesWorkaminoacidantibody based therapiesantibody treatmentantibody-based immunityantibody-based therapeuticsantibody-based treatmentdeep sequencingdesigndesigningdevelop a vaccinedevelop vaccinesdevelopment of a vaccinedevelopmentalgenome mutationhost responseimmune system responseimmunogenimmunoresponseinsightinterestmAbsmonoclonal Absmutation scanningmutation screeningneutralizing antibodyneutralizing mAbneutralizing monoclonal antibodiespandemic concernpandemic potentialpandemic riskpandemic threatpolyclonal antibodypressureprospectiveresponsespillover eventtherapeutically effectivevaccine candidatevaccine developmentviral infectionvirus infectionvirus-induced disease
Description preview
Project Summary/Abstract
Lassa virus is estimated to cause thousands of human deaths each year, primarily due to spillovers from its
natural host, Mastomys rodents. Efforts to create vaccines and antibody therapeutics must account for the
evolutionary variability of Lassa virus’s glycoprotein complex (GPC), which mediates viral entry into cells and…
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