grant
Comprehensive quantification of fuel use in cold-induced thermogenesis in vivo
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 1 Apr 2023Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY20251,2,3-Propanetriol1,2,3-Trihydroxypropane21+ years oldAbnormal Assessment of MetabolismAcuteAdipose tissueAdultAdult HumanAlanineAnimalsArteriesBiologyBloodBlood Reticuloendothelial SystemBody TemperatureBody TissuesBrown Adipose TissueBrown FatBurn injuryBurnsCaloriesCarbohydratesCarbonChronicCitric Acid CycleD-GlucoseDataDevelopmentDextroseExposure toFastingFatsFatty TissueFatty acid glycerol estersFoundationsGlnGluconeogenesisGlucoseGlutamineGlycerinGlycerolGoalsHeat ProductionHexadecanoatesHibernating GlandHumanIndividualInfusionInfusion proceduresInvestigationIsotope LabelingKetonesKineticsKrebs CycleL-GlutamineLabelLiverMammaliaMammalsMapsMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMeasuresMetabolicMetabolic PathwayMetabolic StudiesMetabolism StudiesMiceMice MammalsModern ManMurineMusNatureObesityOrganOrganismPalmitatesPathway interactionsPharmaceutical AgentPharmaceuticalsPharmacologic SubstancePharmacological SubstancePlayPositionPositioning AttributeProcessPyruvateQ LevoglutamideQ. LevoglutamideRoleSkeletal MuscleSolidSourceTCA cycleTechniquesTechnologyTemperatureTestingTherapeuticThermogenesisTissuesTricarboxylic Acid CycleVoluntary MuscleWorkadiposeadiposityadulthoodawakeburnedcarboxylationcorpulencedevelopmentalfastedfastsfatty acid oxidationglucose biosynthesishepatic body systemhepatic organ systemin vivoinfusionsliving systemmetabolic abnormality assessmentmetabolism measurementmetabolomicsmetabonomicsoxidationpathwaypharmaceuticalpyruvate dehydrogenaserecruitsocial rolesugartherapeutic targetwastingwhite adipose tissueyellow adipose tissue
Description preview
SUMMARY
Cold-induced thermogenesis (CIT) allows endotherms, including mammals, to maintain body temperature at
~37oC despite sometimes much colder ambient temperature. Pharmaceutical activation of CIT is being
investigated by many groups as a potential therapeutic approach to obesity. Despite decades of investigations
of CIT, however, how…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click