grant
Comprehensive quantification of fuel use in cold-induced thermogenesis in vivo
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 1 Apr 2023Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY20261,2,3-Propanetriol1,2,3-Trihydroxypropane21+ years oldAbnormal Assessment of MetabolismAcuteAdipose tissueAdultAdult HumanAlanineAnimalsArteriesBiologyBloodBlood Reticuloendothelial SystemBody TemperatureBody TissuesBrown Adipose TissueBrown FatBurn injuryBurnsCaloriesCarbohydratesCarbonChronicCitric Acid CycleD-GlucoseDataDevelopmentDextroseExposure toFastingFatsFatty TissueFatty acid glycerol estersFoundationsGlnGluconeogenesisGlucoseGlutamineGlycerinGlycerolGoalsHeat ProductionHexadecanoatesHibernating GlandHumanIndividualInfusionInfusion proceduresInvestigationIsotope LabelingKetonesKineticsKrebs CycleL-GlutamineLabelLiverMammaliaMammalsMapsMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMeasuresMetabolicMetabolic PathwayMetabolic StudiesMetabolism StudiesMiceMice MammalsModern ManMurineMusNatureObesityOrganOrganismPalmitatesPathway interactionsPharmaceutical AgentPharmaceuticalsPharmacologic SubstancePharmacological SubstancePlayPositionPositioning AttributeProcessPyruvateQ LevoglutamideQ. LevoglutamideRoleSkeletal MuscleSolidSourceTCA cycleTechniquesTechnologyTemperatureTestingTherapeuticThermogenesisTissuesTricarboxylic Acid CycleVoluntary MuscleWorkadiposeadiposityadulthoodawakeburnedcaloriecarboxylationcorpulencedevelopmentalfastedfastsfatty acid oxidationglucose biosynthesishepatic body systemhepatic organ systemin vivoinfusionsliving systemmetabolic abnormality assessmentmetabolism measurementmetabolomicsmetabonomicsoxidationpathwaypharmaceuticalpyruvate dehydrogenaserecruitsocial rolesugartherapeutic targetwastingwhite adipose tissueyellow adipose tissue
Description preview
SUMMARY
Cold-induced thermogenesis (CIT) allows endotherms, including mammals, to maintain body temperature at
~37oC despite sometimes much colder ambient temperature. Pharmaceutical activation of CIT is being
investigated by many groups as a potential therapeutic approach to obesity. Despite decades of investigations
of CIT, however, how…
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