grant
Comprehensive Maps of Early Spliceosome and Regulator Binding to Nascent RNA in Human Cells
Organization UNIVERSITY OF CALIFORNIA LOS ANGELESLocation LOS ANGELES, UNITED STATESPosted 17 Sept 2024Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY20253' Splice Site5' Splice SiteAffectAlternate SplicingAlternative RNA SplicingAlternative SplicingAntigenic DeterminantsBindingBinding DeterminantsBinding SitesCell BodyCell FractionCellsChromatinClinical geneticsCodeCoding SystemCombining SiteComplementComplement ProteinsComplexDNA mutationDataData AnalysesData AnalysisDependenceDetectionElementsEpitopesEventExonsFrequenciesFundingGeneticGenetic ChangeGenetic defectGenetic mutationGenomeGenomicsGoalsHeterogeneous Nuclear Ribonucleoprotein Group HHeterogeneous-Nuclear Ribonucleoprotein Group MHeterogeneous-Nuclear Ribonucleoprotein MHumanIndividualIntervening SequencesIntronsMapsMedical GeneticsMethodsModern ManMolecular AnalysisMolecular InteractionMutationNon-Polyadenylated RNAPathogenicityPatientsPhenotypePolyadenylationPre-mRNAProcessProteinsRNARNA Gene ProductsRNA PolyadenylationRNA SplicingRNA, Messenger, PrecursorsReactionReactive SiteRegulatory ProteinRibonucleic AcidRibonucleoproteins, Small, U1Ribonucleoproteins, Small, U2RoleSilencer ElementsSilencing ElementsSiteSmall Nuclear RNPSmall Nuclear Ribonucleoprotein ParticleSmall Nuclear RibonucleoproteinsSplice Acceptor SitesSplice Donor SitesSpliceosome AssemblySpliceosome Assembly PathwaySpliceosomesSplicingSystemTranscriptTranscriptional Silencer ElementsU1 Small Nuclear RibonucleoproteinU1 snRNPU2 Small Nuclear RibonucleoproteinU2 snRNPVariantVariationWorkcomplementationcrosslinkdata interpretationdisease modeldisorder modelgene functiongenetic regulatory proteingenome mutationgenome scalegenome-widegenomewideglobal gene expressionglobal transcription profilehnRNP MhnRNP-Hhuman diseaseimprovedin vivoinsightmRNA Precursornovelprematureprematurityprotein complexprotein functionregulatory gene productsnRNPsocial roletooltranscriptome
Description preview
PROJECT SUMMARY/ABSTRACT
We propose to develop new methods for the global identification of protein and RNP interactions with nascent
unspliced RNA in human cells. We will use these methods to produce comprehensive binding site maps for
several important molecules in splicing. In previous work, we isolated proteins and RNP’s from the chromatin…
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