grant
Complement convertase imaging techniques for optimization of complement therapeutic amelioration of antibody mediated rejection
Organization NORTHWESTERN UNIVERSITYLocation CHICAGO, UNITED STATESPosted 1 Apr 2026Deadline 31 Mar 2030
NIHUS FederalResearch GrantFY2026AcuteAntibodiesAntibody TherapyAreaB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellBindingBiopsyBlood NeutrophilBlood Polymorphonuclear NeutrophilBlood monocyteC 3 ConvertaseC 4dC3 ActivatorC3 ConvertaseC3 dC3-C5 ConvertaseC3dC4dC5 Cleaving EnzymeC5 ConvertaseC5 aC5aCardiac TransplantationCathepsin B1Cathepsins BCell FunctionCell PhysiologyCell ProcessCellular FunctionCellular PhysiologyCellular ProcessChronicClinicalClottingCoagulationCoagulation ProcessComplementComplement 3 ConvertaseComplement 3dComplement 5 ConvertaseComplement 5aComplement ActivationComplement C3dComplement C5aComplement InactivatorsComplement InhibitorsComplement ProteinsComplexCytotoxic cellDepositDepositionDevelopmentDiagnosisDiseaseDisorderDysfunctionEAC 423EAC142EC 3.4.22.1EndotheliumEsteroproteasesFamily suidaeFunctional disorderGeneral RadiologyGoalsGraft RejectionGrafting ProcedureGranzymeHL-A AntigensHLA AntigensHeart GraftingHeart TransplantationHumanHuman Leukocyte AntigensIgG ReceptorsImageImaging ProceduresImaging TechnicsImaging TechniquesImmuneImmune systemImmunesImmunoglobulin G ReceptorIn VitroInflammationInflammatoryInjuryInnate ImmunityInterventionInvestigationK lymphocyteLeukocyte AntigensLeukocyte TraffickingLungLung GraftingLung Respiratory SystemLung TransplantationMarrow NeutrophilMarrow monocyteMediatingMedicalModelingModern ManMolecular InteractionMonitorMyocarditisNK CellsNative ImmunityNatural ImmunityNatural Killer CellsNeutrophilic GranulocyteNeutrophilic LeukocyteNon-Invasive DetectionNon-Specific ImmunityNoninvasive DetectionNonspecific ImmunityOrgan TransplantationOrgan TransplantsOutcomePathogenesisPathway interactionsPatientsPeptidasesPeptide HydrolasesPerfusionPhagocytesPhagocytic CellPhysiopathologyPigsPlasmapheresisPolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsProceduresProcessProtease GeneProteasesProteinasesProteinsProteolytic EnzymesPulmonary GraftPulmonary TransplantPulmonary TransplantationRadiologyRadiology SpecialtyRecombinant C5aReportingResearchRodentRodentiaRodents MammalsSerologySiteStratificationSubcellular ProcessSuidaeSwineSystemT-CellsT-LymphocyteTechniquesTherapeuticTherapeutic InterventionTherapeutic Plasma ExchangeTherapeutic PlasmapheresisTimeTransgenic AnimalsTranslatingTransplant RejectionTransplantationTransplantation RejectionTreatment EfficacyTreatment ProtocolsTreatment RegimenTreatment ScheduleWorkamebocyteanalogantibody based therapiesantibody rejectionantibody treatmentantibody-based therapeuticsantibody-based treatmentantibody-mediated rejectioncardiac graftcardiac inflammationclinical applicabilityclinical applicationclinical translationclinically translatablecomplement 4dcomplement C4dcomplement pathwaycomplement pathway regulationcomplementationcustomized therapycustomized treatmentdetection methoddetection proceduredetection techniquedevelopmentaldonor antibodiesdonor-specific antibodyex vivo perfusionfluorescence imagingfluorescent imaginggamma Fc Receptorsgraft dysfunctionheart transplantimage-based methodimagingimaging agentimaging methodimaging modalityimaging probeimprovedimproved outcomein vivoindividualized medicineindividualized patient treatmentindividualized therapeutic strategyindividualized therapyindividualized treatmentinjuriesintervention efficacyintervention therapylung transplantminimally invasivemonocytemouse modelmurine modelneutrophilnon-invasive diagnosisnon-invasive diagnosticnon-invasive monitornoninvasive diagnosisnoninvasive diagnosticnoninvasive monitornovelorgan allograftorgan graftorgan xenograftpathophysiologypathwaypatient specific therapiespatient specific treatmentpatient stratificationporcinepre-clinicalpreclinicalstratified patientsuccesssuidtailored medical treatmenttailored therapytailored treatmenttherapeutic efficacytherapy efficacythymus derived lymphocytetooltransplantunique treatment
Description preview
PROJECT SUMMARY/ABSTRACT
Therapeutic strategies to halt antibody-mediated rejection (AMR) following lung transplantation are lacking, due
in large part to the complex pathophysiology of the immune process and the multi-faceted approach that must
be taken to establish a defined diagnosis. It is becoming increasingly clear that AMR has many…
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