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Comparison of direct and indirect magnetic resonance imaging of myelin in Alzheimer's disease
Organization UNIVERSITY OF CALIFORNIA, SAN DIEGOLocation LA JOLLA, UNITED STATESPosted 1 Apr 2023Deadline 31 Mar 2026 ⚠️
NIHUS FederalResearch GrantFY20250-11 years old3-D3-Dimensional3DAD dementiaAction PotentialsAffectAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's diagnosisAlzheimer's disease diagnosisAlzheimer's disease patientAlzheimer's patientAlzheimers DementiaAmentiaAmyloid (Aβ) plaquesAmyloid PlaquesAxonal TransportAxoplasmic TransportBiologicalBody TissuesBrainBrain Nervous SystemBrain imagingCadaverCell Communication and SignalingCell SignalingChildChild DevelopmentChild YouthChildren (0-21)ClinicalClinical dementia rating scaleCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalComplexCross Sectional AnalysisCross-Sectional AnalysesCross-Sectional StudiesCross-Sectional SurveyDementiaDementia rating scaleDemyelinationsDepositDepositionDetectionDevelopmentDiagnosisDiseaseDisease Frequency SurveysDisease ProgressionDisorderDisturbance in cognitionDropsyEdemaEncephalonEvaluationEventFe elementFellowshipFundingGenerationsGoalsGrantH+ elementHistologyHumanHydrogen IonsHydrogen OxideHydropsImageImaging ProceduresImaging TechnicsImaging TechniquesImpaired cognitionImpairmentInfant and Child DevelopmentInflammationIntracellular Communication and SignalingIronLearningMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMaintenanceMapsMeasuresMechanicsMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMentorsModern ManMonitorMotor SkillsMyelinNMR ImagingNMR TomographyNerve DegenerationNeuritic PlaquesNeurofibrillary TanglesNeuron DegenerationNuclear Magnetic Resonance ImagingOligodendrocytesOligodendrocytusOligodendrogliaOligodendroglia CellParticipantPathogenesisPatientsPhysiologic pulsePlayPowder dose formPowdersPregnant WomenPrimary Senile Degenerative DementiaProductivityProtocolProtocols documentationProtonsPulseRecoveryReference StandardsRefractoryRegistriesRelaxationResearchResearch SpecimenRoleSamplingSenile PlaquesSensitivity and SpecificitySignal TransductionSignal Transduction SystemsSignalingSpecimenSpeedSuspension substanceSuspensionsTechniquesTimeTissuesTrainingTranslational ResearchTranslational ScienceTransmissionVendorVesicleWaterZeugmatographyabsorptionamyloid beta plaqueamyloid-b plaqueaβ plaquesbiologicbiological signal transductionbrain visualizationcadavericcadaverscareercognitive assessmentcognitive dysfunctioncognitive functioncognitive losscognitive testingcohortcommercializationcored plaquedata acquisitiondata acquisitionsdemyelinatedesigndesigningdetection methoddetection proceduredetection techniquedevelopmentaldiagnostic approachdiagnostic strategydiffuse plaquedisabilityexpectant motherexpectant womenexpecting motherexpecting womenextracellulargray matterhealthy volunteerimagingimaging in vivoimprovedin vivoin vivo imagingindividuals who are pregnantkidsmechanicmechanicalmental statemental statusmild cognitive disordermild cognitive impairmentmotor abilityneural degenerationneurodegenerationneurodegenerativeneurofibrillary degenerationneurofibrillary lesionneurofibrillary pathologyneurological degenerationneuronal degenerationnew diagnosticsnext generation diagnosticsnon-invasive imagingnoninvasive imagingnovelnovel diagnosticspatient living with Alzheimer's diseasepatient suffering from Alzheimer's diseasepatient with Alzheimer'spatient with Alzheimer's diseasepeople who are pregnantpregnant femalespregnant motherspregnant peoplepregnant populationspreventpreventingprimary degenerative dementiasenile dementia of the Alzheimer typesimulationsocial rolesubstantia albasubstantia griseatanglethose who are pregnantthree dimensionaltranslation researchtranslational investigationtransmission processwhite matterwomen who are pregnantyoungster
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PROJECT SUMMARY/ABSTRACT
Alzheimer’s Disease (AD) is the leading cause of dementia characterized by progressive cognitive decline.
The underlying causes remain poorly understood after decades of efforts, and the disease still cannot be cured,
prevented, or significantly delayed. Myelin impairment can disrupt axonal transport, integrity, and…
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