grant
Comparative Effectiveness and Safety of Metabolic/Bariatric Surgery, GLP-1, and SGLT-2 Medications for Patients with Obesity and Type 2 Diabetes
Organization KAISER FOUNDATION RESEARCH INSTITUTELocation Oakland, UNITED STATESPosted 6 Mar 2024Deadline 29 Feb 2028
NIHUS FederalResearch GrantFY2025Acute Kidney FailureAcute Kidney InsufficiencyAcute Renal FailureAcute Renal InsufficiencyAdult-Onset Diabetes MellitusAffectAgeAgonistAmericanBenefits and RisksBlood PressureBlood VesselsBody Weight decreasedCessation of lifeClinicalClinical Practice GuidelineClinical TrialsCo-TransportersComparative Effectiveness ResearchComplications of Diabetes MellitusD-GlucoseDataData BasesDatabasesDeathDextroseDiabetes ComplicationsDiabetes MellitusDiabetes-Related ComplicationsDiabetic AcidosisDiabetic ComplicationsDiabetic KetoacidosisDiabetic KetosisDisease ProgressionDrug TherapyDrugsED careED visitER careER visitEffectivenessElectronic Health RecordEligibilityEligibility DeterminationEmergency CareEmergency Department careEmergency Room careEmergency care visitEmergency department visitEmergency health careEmergency hospital visitEmergency medical careEmergency room visitEnrollmentEthnic OriginEthnicityEventFee-for-Service PlansFees for ServiceGLP-1GLP-1 receptorGLP-I receptorGU InfectionGastrectomyGastric BypassGenderGenitourinary System InfectionGenitourinary infectionGlp-1GlucoseGlycohemoglobin AGlycosylated hemoglobin AHb A1Hb A1a+bHb A1cHbA1HbA1cHeadHealth Insurance for Aged and Disabled, Title 18Health Insurance for Disabled Title 18Hemoglobin A(1)Hospital AdmissionHospitalizationHyperglycemiaHypoglycemiaIncidenceInsurance CoverageInsurance StatusKetosis-Resistant Diabetes MellitusKidneyKidney DiseasesKidney Urinary SystemKnowledgeLife StyleLifestyleLinkLongitudinal StudiesMaturity-Onset Diabetes MellitusMedicalMedicareMedicationMetabolicMicrovascular DysfunctionNIDDMNa elementNephropathyNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusObesityOperative ProceduresOperative Surgical ProceduresOutcomePatientsPharmaceutical AgentPharmaceutical PreparationsPharmaceuticalsPharmacologic SubstancePharmacological SubstancePharmacological TreatmentPharmacotherapyProtocol ScreeningRaceRacesRandomization trialRandomized, Controlled TrialsRecommendationRenal DiseaseReoperationRepeat SurgeryResearchResearch DesignRiskSafetySample SizeSamplingSelection for TreatmentsSeveritiesSlow-Onset Diabetes MellitusSodiumStable Diabetes MellitusStudy TypeSubgroupSurgicalSurgical InterventionsSurgical ProcedureT2 DMT2DT2DMTherapeuticTitle 18Treatment CostType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesWeightWeight LossWeight ReductionWeight maintenance regimenWorkacute kidney injuryadiposityadult adiposityadult obesityadult onset diabetesadults with obesityagesalternative treatmentbariatric surgeryblood glucose regulationbody weight lossclinical practice and guidelinesco-morbidco-morbiditycohortcomorbiditycomparative effectivenesscomparative effectiveness studycomparative safetycompare effectivenesscorpulencecostdata basedata collected in real worlddiabetesdiabetes mellitus therapydiabetes therapydiabetic ketoacidoticdrug interventiondrug treatmentdrug/agentelectronic health care recordelectronic health medical recordelectronic health plan recordelectronic health registryelectronic medical health recordenrollethnic minorityethnic minority groupethnic minority individualethnic minority peopleethnic minority populationgastric bandinggastric bypass surgeryglucagon-like peptide 1glucagon-like peptide-1 receptorglucose controlglucose homeostasisglucose regulationglycemic controlhazardhealth insurance for disabledhemoglobin A1chigh risk grouphigh risk individualhigh risk peoplehigh risk populationhospitalization rateshyperglycemichypoglycemichypoglycemic episodesimplantable gastric stimulation bandingimprovedinfectious disease of genitourinary systeminhibitorketosis resistant diabeteskidney disorderlong-term studylongitudinal outcome studiesmacrovascular complicationmacrovascular diseasematurity onset diabetesmicrovascular complicationsmicrovascular diseasemortalityobese patientsobesity interventionobesity managementobesity surgeryobesity therapyobesity treatmentpatient populationpatient subclasspatient subclusterpatient subgroupspatient subpopulationspatient subsetspatient subtypespatients with obesitypharmaceuticalpharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspreventpreventingprospectiveracialracial backgroundracial minorityracial minority groupracial minority individualracial minority peopleracial minority populationracial originrandomized control trialrandomized trialreal world datarenalrenal disorderresearch studyrural dwellersrural residentsafety outcomessafety studyselection of treatmentsmall vessel diseasestomach bypassstomach staplingstudy designsurgerysurgery risksurgical risksymportertherapy selectiontreatment selectiontype 2 DMtype II DMtype two diabetesuptakeurogenital infectionvascularweight controlweight loss surgeryweight managementweightswt-loss
Description preview
PROJECT SUMMARY
More than 12 million Americans currently live with both obesity and type 2 diabetes (T2D), putting them in one
of the highest risk groups for developing serious microvascular and macrovascular complications. The Ameri-
can Diabetes Association’s clinical practice guidelines recommend metabolic/bariatric surgery (MBS) and/or…
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