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Combined environmental exposures and neurodevelopment disorders

Organization UNIVERSITY OF CALIFORNIA AT DAVISLocation DAVIS, UNITED STATESPosted 1 May 2024Deadline 30 Apr 2026 ⚠️
NIHUS FederalResearch GrantFY20250-11 years old21+ years oldASDAcuteAddressAdultAdult HumanAffectAir PollutionAllergic asthmaAllergyAsthmaAutismAutism DiagnosisAutistic DisorderAutopsyBrainBrain DiseasesBrain DisordersBrain Nervous SystemBronchial AsthmaCaliforniaCell BodyCell NucleusCellsCellular Immune FunctionChildChild YouthChildren (0-21)ComplexDNA MethylationDataDeveloping fetusDevelopmentDifferences between sexesDiffers between sexesDiseaseDisorderDroughtsDrug TherapyDysfunctionEarly Infantile AutismEncephalonEncephalon DiseasesEndotheliumEnvironmental ExposureEnvironmental FactorEnvironmental PollutantsEnvironmental Risk FactorEpidemiologyEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEpitheliumExhibitsExposure toExtrinsic asthmaFaceFactor AnalysesFactor AnalysisFetal DevelopmentFeverFire - disastersFiresFunctional disorderGene Action RegulationGene ExpressionGene Expression RegulationGene RegulationGene Regulation ProcessGenesGeneticGenomicsGestationGoalsGrainHeritabilityHortega cellHospital AdmissionHospitalizationHumanImmuneImmune Cell ActivationImmune responseImmune systemImmunesImmunochemical ImmunologicImmunologicImmunologicalImmunologicallyImmunologicsImmunomodulationImpairmentIn SituInfantile AutismInflammatoryInflammatory ResponseIntracranial CNS DisordersIntracranial Central Nervous System DisordersInvestigationKanner's SyndromeLaboratoriesLeadLifeLinkLiquid substanceMediatingMethylationMiceMice MammalsMicrogliaModelingModern ManModificationMolecularMorphologyMurineMusNerve CellsNerve Transmitter SubstancesNerve UnitNeural CellNeural DevelopmentNeurobiologyNeurocyteNeurodevelopmental DisorderNeurological Development DisorderNeuronsNeurotransmittersNucleusObservational epidemiologyParticulate MatterPathway interactionsPatternPb elementPhagocytosisPharmacological TreatmentPharmacotherapyPhysiopathologyPollutionPre-Clinical ModelPreclinical ModelsPredispositionPregnancyPreventative strategyPreventionPrevention strategyPreventive strategyProcessPublic HealthPyrexiaRNA SeqRNA sequencingRNAseqRegulatory PathwayReportingResearchRiskSamplingSeasonsSex DifferencesSexual differencesSocial InteractionSolidSootSourceSusceptibilitySynapsesSynapticTestingTimeTranslatingUnited StatesWildfireWomanadulthoodallergic airway diseaseasthma attackasthma exacerbationasthmaticatopic asthmaautism modelautism spectral disorderautism spectrum disorderautistic childrenautistic spectrum disorderbrain tissuechildren on the autism spectrumchildren with ASDchildren with autismchildren with autism spectrum disorderclimate changeclimatic changescritical periodcytokinedevelopmentaldiscover genesdisease riskdisorder riskdrug interventiondrug treatmenteffective therapyeffective treatmentenvironmental contaminantenvironmental riskepidemiologicepidemiologicalepigenetic regulationepigeneticallyepigenomeepigenomicsexacerbation in asthmaexacerbation prone asthmaexacerbation prone asthmaticexperimentexperimental researchexperimental studyexperimentsextrinsic allergic asthmafacesfacialfebrilefebrisfetalfirefluidgene discoverygene networkgitter cellglial activationglial cell activationglial cell developmentglial developmentglobal climate changeglobal gene expressionglobal transcription profileheavy metal Pbheavy metal leadhost responseimmune activationimmune functionimmune modulationimmune regulationimmune system responseimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryimmunoresponseinnovateinnovationinnovativeinterestkidsliquidmaternal immune systemmesogliamicroglial cellmicrogliocytemodel of autism spectrum disordermother immune systemmultiomicsmultiple omicsnecropsyneurobiologicalneurodevelopmentneurodevelopmental diseaseneuronalnoveloffspringpanomicspathophysiologypathwayperivascular glial cellpharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspostmortempregnantprenatalpreventpreventingrepetitive behaviorresponsesexsex based differencessex-dependent differencessex-related differencessex-specific differencessynapsetranscriptometranscriptome sequencingtranscriptomic sequencingunbornwild firewildland fireyoungster

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Project Summary/Abstract: Autism spectrum disorders (ASD) are pervasive, highly prevalent lifelong
disorders for which pharmacological interventions are not readily available. While genetic factors are likely
contributors to these disorders, heritability estimates indicate strong environmental contributions. Of significant
interest is the link…

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