grant
Combinatorial targeting for the treatment of B-cell acute lymphoblastic leukemia
Organization WEST VIRGINIA UNIVERSITYLocation MORGANTOWN, UNITED STATESPosted 1 Aug 2018Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY2025AcuteAcute B-Lymphocytic LeukemiaB Cell ProliferationB blood cellsB cellB cell progenitor acute lymphoblastic leukemiaB cellsB-ALLB-Cell Acute Lymphocytic LeukemiaB-Cell Acute Lymphoblastic LeukemiaB-Cell Lymphoblastic LeukemiaB-CellsB-LymphocytesB-cellB-cell ALLB-cell precursor acute lymphoblastic leukemiaBCR-ABLBCR-ABL OncoproteinBCR-ABL Protein Tyrosine KinaseBCR/ABLCell BodyCell Communication and SignalingCell SignalingCellsChargeChromosomesDataDevelopmentDiagnosisEncapsulatedGenesHandIn VitroIntracellular Communication and SignalingKineticsLigandsLipLip structureMGF proteinMGSNF proteinMitochondrial ProteinsModelingNucleic AcidsPhiladelphiaPre-B-Cell LeukemiaPrecursor B Lymphoblastic LeukemiaRelapseSTAT proteinSTAT5STAT5ASTAT5A geneSTAT5a Transcription FactorShort interfering RNASignal Transducer and Activator of TranscriptionSignal Transducer and Activator of Transcription 5ASignal TransductionSignal Transduction SystemsSignalingSmall Interfering RNASolventsStat5 proteinStat5a proteinStat5alpha proteinSubgroupSystemTechnologyTestingTherapeuticTumor BurdenTumor Loadantileukemic activityaqueousbcr-abl Fusion Proteinsbiological signal transductioncancer microenvironmentcombinatorialdevelopmentalhandshigh riskhydrophilicityin vivoinnovateinnovationinnovativeknock-downknockdownlipid based nanoparticlelipid nanoparticlemammary gland factormammary gland-specific nuclear factornano particlenano-sized particlenanoparticlenanosized particlesiRNAsignal tranducer and activator of transcription 5small moleculesmall molecule therapeuticstreatment strategytumor microenvironment
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Description preview
B-cell acute IympnooIast1c IeuKemIa (ALL) accounts for 75% of all ALL diagnoses. Specifically, treating the Philadelphia {Ph) chromosome subgroup (which creates a new gene called BCR-ABL) of B-cell ALL challenging and has high relapse rates and poor survival. Mounting evidence from recent findings suggest that Signal Transducer and Activator of…
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