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Combating the Immunosuppressive Tumor Microenvironment in Triple Negative Breast Cancer: The Role of Mitochondrial Dynamics in the Polarization of Tumor-Associated Macrophages
Organization BAYLOR COLLEGE OF MEDICINELocation HOUSTON, UNITED STATESPosted 1 Jan 2022Deadline 30 Jun 2025 ⚠️
NIHUS FederalResearch GrantFY2025AdoptedAerobicAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryBreast CancerCancer CauseCancer EtiologyCancer PrognosisCategoriesCausalityCell FunctionCell PhysiologyCell ProcessCellular FunctionCellular PhysiologyCellular ProcessCharacteristicsClassificationComplexCyclicityDataDevelopmentDiagnosisDifferentiation in cell cultureDiseaseDisorderDrug resistanceElectron TransportElementsEndocrineEnvironmentEtiologyExpression SignatureFoundationsGene ExpressionGene Expression ProfileGeneralized GrowthGenesGlycolysisGoalsGrowthHumanImmuneImmune infiltratesImmune mediated therapyImmunesImmunologically Directed TherapyImmunosuppressionImmunosuppression EffectImmunosuppressive EffectImmunotherapyImpairmentIn VitroIn vitro cell differentiationInflammatoryIntermediary MetabolismLength of LifeLongevityLytotoxicityMacrophageMalignant Breast NeoplasmMediatingMetabolicMetabolic ProcessesMetabolismMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic TumorMethodsMiceMice MammalsMitochondriaModelingModern ManMolecularMurineMusMφNeoplasm MetastasisOxidative PhosphorylationOxidative Phosphorylation PathwayPathway interactionsPatientsPeriodicityPhenotypePopulationPositionPositioning AttributePrognosisRegulationResistanceRhythmicityRoleSecondary NeoplasmSecondary TumorStructureSubcellular ProcessSystematicsT-CellsT-LymphocyteT-StageTNBCTestingTherapeuticTissue GrowthTumor stageTumor-associated macrophagesTumor-infiltrating immune cellsWomen's mortalityWorkangiogenesisbreast cancer survivalcancer metastasiscancer microenvironmentcancer progressioncancer sub-typescancer subtypescausationcheck point blockadecheckpoint blockadechemotherapycytotoxiccytotoxicitydeath among femalesdeath among womendeath in femalesdeath in womendeath rate among womendeath rate in womendevelopmentaldifferentiation in culturedifferentiation in vitrodisease causationdrug resistantdrug-sensitiveelectron transferexperiencefemale deathfemale mortalityflexibilityflexiblegene expression patterngene expression signatureimmune cell infiltrateimmune cell infiltration of tumorsimmune cells infiltrating the tumorimmune cells that infiltrate the tumorimmune check point blockadeimmune checkpoint blockadeimmune microenvironmentimmune suppressionimmune suppressive activityimmune suppressive functionimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyimmunogenicimmunogenicityimmunosuppressive activityimmunosuppressive functionimmunosuppressive microenvironmentimmunosuppressive responseimmunosuppressive tumor microenvironmentin vitro cellular differentiationin vivoinfiltration of tumors by immune cellsinnovateinnovationinnovativeinsightintratumoral immune cellintratumoral immune infiltratemalignant breast tumormammarymitochondrialmortality among femalesmortality among womenmortality in femalesmortality in womenneoplasm progressionneoplastic progressionnovelontogenypathwaypreferenceprogramsprotein expressionresistance to Drugresistantresistant to Drugrespiratorysocial rolesuccesstherapeutic targetthymus derived lymphocytetranscriptional profiletranscriptional signaturetransplant modeltriple-negative breast cancertriple-negative invasive breast carcinomatumortumor cell metastasistumor growthtumor immune celltumor immune infiltratetumor immune microenvironmenttumor infiltration of immune cellstumor microenvironmenttumor progressiontumor-immune system interactionswomen's deathwomen's death rate
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Project Summary/Abstract
Triple Negative Breast Cancer (TNBC) is a devastating disease with aggressive growth and frequent metastases.
Less than 30% of patients with metastatic TNBC survive beyond five years after their diagnosis. While other
breast cancer subtypes have well-defined endocrine markers, TNBC tumors lack such specific therapeutic…
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