grant
Collaborative Pathways that Lead to Leukemia
Organization DIVISION OF BASIC SCIENCES - NCILocation UNITED STATES
NIHUS FederalResearch GrantFY20251, 2-Dehydrocortisone1.beta.-D-Arabinofuranosylcytosine3' Untranslated Regions3'UTR98 kD Nucleoporin98-kD Gene NucleoporinABC20ABCB1ABCB1 geneABL1ABL1 geneADIR2ARA-cellAbelson Murine Leukemia Viral Oncogene Homolog 1Acute B-Lymphocytic LeukemiaAcute leukemiaAlexanAllelesAllelomorphsAnimal ModelAnimal Models and Related StudiesAnti-OncogenesAntioncogenesApoptosisApoptosis PathwayArabineArabinofuranosylcytosineArabinosylcytosineAracytidineAracytinAracytineB blood cellsB cellB cell progenitor acute lymphoblastic leukemiaB cellsB-ALLB-Cell Acute Lymphocytic LeukemiaB-Cell Acute Lymphoblastic LeukemiaB-Cell Lymphoblastic LeukemiaB-CellsB-LymphocytesB-cellB-cell ALLB-cell precursor acute lymphoblastic leukemiaBlood Precursor CellCAIN GeneCAN ProteinCAN geneCRISPR editing screenCRISPR screenCRISPR-based screenCRISPR/Cas9 screenCancer GenesCancer Suppressor GenesCancer-Promoting GeneCancersCandidate Disease GeneCandidate GeneCell BodyCell LineCellLineCellsChemoresistanceCollaborationsComplexCytarabineCytarabinumCytarbelCytidineCytosarCytosar-UCytosarUCytosine ArabinosideCytosine RibonucleosideCytosine RibosideCytosine-.beta.-arabinosideD9S46EDCK geneDHFRDHFR geneDNA HelicasesDNA ReplicationDNA ResequencingDNA SynthesisDNA Unwinding ProteinsDNA biosynthesisDNA mutationDNA replication forkDNA unwinding enzymeDehydrocortisoneDelta(1)-CortisoneDeltacortisoneDeltadehydrocortisoneDeoxycytidine Kinase GeneEPEGEmerogenesEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEposideErpalfaEtoposideGEM modelGEMM modelGLFG-Repeat Containing NucleoporinGP170Gene Copy NumberGene DosageGenerationsGenesGeneticGenetic ChangeGenetic defectGenetic mutationGenetically Engineered MouseGenetsGenomic DNAGerminoblastic SarcomaGerminoblastomaHematopoietic Progenitor CellsHematopoietic stem cellsHumanImpairmentInsertional MutagenesisJTK7KIAA0023KinasesKnock-inLastetLengthLeurocristineLicensing FactorLymphoblastic LeukemiaLymphocytic LeukemiaLymphoid LeukemiaLymphomaMDR-1MDR1MDR1 ProteinMaintenanceMalignant LymphomaMalignant NeoplasmsMalignant TumorManuscriptsMetacortandracinMethotrexateMethotrexate MethylaminopterinMethotrexatumMetotrexatoMiceMice MammalsModern ManMouse StrainsMultidrug Resistance 1Multidrug Resistance Gene-1Multidrug Resistance Gene-1sMultidrug Resistance ProteinsMultidrug Resistant ProteinsMurineMusMutationMyelogenousMyeloidNUP196NUP214NUP214 geneNUP96 GeneNUP98NUP98 geneNUP98-NUP96 PrecursorNuclear Pore Complex Protein NUP98Nucleoporin 214kDaNucleoporin 98kDNucleoporin NUP98Nucleoporin, 214-KDOnco-Suppressor GenesOncogenesOncogenes-Tumor SuppressorsP-GPP-GlycoproteinP-Glycoprotein 1 GenePGY-1 ProteinPGY1PTP-1BPTP1BPTPN1PTPN1 genePathway interactionsPatternPhenotypePhosphorylationPhosphotransferase GenePhosphotransferasesPlacental Protein-Tyrosine phosphatasePre-B-Cell LeukemiaPrecursor B Lymphoblastic LeukemiaPrednisonePrednisonumProgrammed Cell DeathProliferatingProtein PhosphorylationProtein Phosphotyrosylphosphatase 1BProteinsPublicationsPublishingRNA SplicingRecessive OncogenesRecurrenceRecurrentReportingResequencingResistanceReticulolymphosarcomaSamplingScientific PublicationSplicingStrains Cell LinesT leukemia cellT-ALL cellT-Cell LeukemiaT-Cell Lymphocytic LeukemiaT-CellsT-LymphocyteT-Lymphocytic LeukemiaTOP1TOP1 geneTarabine PFSTestingTransforming GenesTransgenesTransphosphorylasesTumor Suppressing GenesTumor Suppressor GenesUdicilVepesidVincristineVincrystineacute T-cell lymphoblastic leukemia cellacute T-cell lymphocytic leukemia cellblood cell progenitorblood progenitorblood stem cellblood-forming stem cellc-Ablc-abl Genesc-abl Proto-Oncogenescell typechemoresistantchemotherapy resistancechemotherapy resistantclustered regularly interspaced short palindromic repeats screencopy number alterationcultured cell linedelta-Cortisoneentire genomeepigeneticallyexome sequencingexome-seqfull genomegDNAgenetically engineered mouse modelgenetically engineered murine modelgenome mutationhelicasehematopoietic progenitorhematopoietic stem progenitor cellhemopoietic progenitorhemopoietic stem cellknockinleukemialeukemia/lymphomaleukemic transformationlymphatic leukemialymphogenous leukemialymphoma/leukemiamalignancymodel of animalmutantneoplasm/cancernew approachesnovelnovel approachesnovel strategiesnovel strategynuclear pore complex protein 98oncosuppressor geneoxovincaleukoblastinepathwayprogenitor cell regenerationprogenitor cell self renewalprogenitor regenerationprogenitor self renewalprotein tyrosine phosphatase, non-receptor type 1replication forkresistantretroviral transductionshRNAshort hairpin RNAsmall hairpin RNAstemstem and progenitor cell regenerationstem and progenitor cell self renewalstem cell regenerationstem cell self renewalthymus derived lymphocytetransgenewhole genome
Description preview
Mini-chromosome maintenance component 2 (Mcm2) is a DNA replication licensing factor that is part of the Mcm2-7 complex which functions as a DNA helicase, unwinding genomic DNA at the replication fork. Not surprisingly, homozygous deletion of Mcm2 is lethal. However, insertion of a cre cassette into the 3' UTR of Mcm2 leads to ~ 50% reduction in…
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