grant
Cohort Studies of HIV/AIDS and Substance Use in Miami
Organization FLORIDA INTERNATIONAL UNIVERSITYLocation MIAMI, UNITED STATESPosted 30 Sept 2025Deadline 30 Jun 2030
NIHUS FederalResearch GrantFY202521+ years oldAIDS VirusAIDS/HIVAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAddressAdultAdult HumanAffectBrainBrain Nervous SystemCaringCharacteristicsClinicalCocaineCocaine AbuseCognitiveCohort StudiesCollaborationsCommunitiesConcurrent StudiesDNA MethylationDataData BasesDatabasesDetectionDeteriorationDropoutDrug abuseEWASEarly identificationEncephalonEnrollmentEnvironmentEpidemicEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEquityGenomeGoalsGuidelinesHIVHIV/AIDSHealthHealth CareHealth PolicyHealth PromotionHistonesHistoryHuman Immunodeficiency VirusesIQ DeficitInfrastructureInterdisciplinary ResearchInterdisciplinary StudyIntervention StrategiesInvestigatorsLAV-HTLV-IIILinkLocalesLongitudinal StudiesLymphadenopathy-Associated VirusMRI ScansMagnetic Resonance Imaging ScanMethodsModelingModificationMultidisciplinary CollaborationMultidisciplinary ResearchNIDANational Institute of Drug AbuseNational Institute on Drug AbuseNational Institutes of HealthNatureNeurocognitionNeurocognitiveNeurocognitive DeficitOutcomePBMCParticipantPathologyPatternPeripheral Blood Mononuclear CellPersonsPhenotypePhysiologicPhysiologicalPopulationPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingProtein ModificationPublic HealthPublicationsQOL improvementRecording of previous eventsResearchResearch PersonnelResearch PriorityResearch SpecimenResearchersRiskSalutogenesisScientific PublicationServicesSpecimenStructureSubstance abuse problemTimeUnited States National Institutes of HealthViralVirus-HIVVisitWomanWorkabuse of drugsabuse of substancesabuses drugsadulthoodaged groupaged groupsaged individualaged individualsaged peopleaged personaged personsaged populationaged populationsaging populationbiobankbiorepositorychromatin remodelingclinical predictorsco-morbidco-morbiditycocaine usecohortcomorbiditydata basedecrease disabilitydecrease in disabilitydiagnostic approachdiagnostic biomarkerdiagnostic markerdiagnostic strategydisabilitydisability reductionenrollepigenetic biomarkerepigenetic markerepigeneticallyepigenome wide association analysisepigenome-wide association studiesfrailtyhealth care policyhistoriesimplementation scienceimprovedimprovements in QOLimprovements in quality of lifeinsightintelligence quotient deficitlessen disabilitylong-term studylongitudinal outcome studiesmicrobiomeminimize disabilitymitigate disabilitymortalitymulti-modal neuro-imagingmulti-modalitymultidisciplinarymultimodal neuroimagingmultimodalityneural imagingneuro-imagingneurocognitive declineneurocognitive impairmentneuroimagingneurological imagingnovelpoor health outcomepopulation agingprecision medicineprecision-based medicinepredictive signaturepromoting healthquality of life improvementrecruitreduced health outcomereduction in disabilitysexslow disabilitysocialsocial factorsstructural determinantsstructural factorssubstance abusesubstance abuse therapysubstance abuse treatmentsubstance usesubstance usingworse health outcome
Description preview
This is a proposal for the continuation of the well-characterized Miami Adult Studies on HIV (MASH) cohort of middle-to-old, aged people living with and without HIV and substance use followed biannually, with a history of multidisciplinary collaboration. After 3% yearly dropout, MASH (n=1,439) has people living with HIV & cocaine use (n=231), HIV…
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