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Cognitive and Affective Network Dysfunction and Neuromodulation in Aging and Synucleinopathy

Organization UNIVERSITY OF FLORIDALocation GAINESVILLE, UNITED STATESPosted 1 May 2021Deadline 30 Apr 2026 ⚠️
NIHUS FederalResearch GrantFY2025AD dementiaAD modelAD related dementiaADRDAddressAffectAffectiveAffective SymptomsAgeAge of OnsetAgingAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's and related dementiasAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease modelAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease patientAlzheimer's disease related dementiaAlzheimer's patientAlzheimers DementiaAmentiaAnimal ModelAnimal Models and Related StudiesAnxietyAttentionAttenuatedBehaviorBehavior assessmentBehavioralBehavioral MechanismsBiological MarkersBrainBrain Nervous SystemCell BodyCellsCharacteristicsCognitionCognitiveCognitive DisturbanceCognitive ImpairmentCognitive ManifestationsCognitive SymptomsCognitive declineCognitive deficitsCognitive function abnormalCommon Rat StrainsCorpus StriatumCorpus striatum structureDataDementiaDiseaseDisorderDisturbance in cognitionDorsalDysfunctionElderlyEncephalonExecutive DysfunctionExecutive Function DeficitExecutive ImpairmentExhibitsFamilyFunctional MRIFunctional Magnetic Resonance ImagingFunctional disorderFutureGoalsHallucinationsHumanImmediate MemoryImpaired cognitionImpairmentImpulsivityInjectionsLB dementiaLaboratoriesLewy Body DementiaLewy Body Type Senile DementiaLewy dementiaLinkMechanisms of Behavior and Behavior ChangeMemoryMental DepressionMentorsMiceMice MammalsModelingModern ManMotivationMotorMotor CortexMurineMusNAC precursorNerve DegenerationNeurobehavioral ManifestationsNeurobehavioral Signs and SymptomsNeuron DegenerationOutcomePARK1 proteinPARK4 proteinPD with dementiaParkinson Disease dementiaParkinson's DementiaParkinson's disease with dementiaPathogenicityPathologicPathologyPatientsPatternPhenotypePhysiopathologyPrefrontal CortexPrimary Senile Degenerative DementiaProteinsPublishingQOLQuality of lifeRatRats MammalsRattusResearchRestRewardsRisk FactorsRoleSNCASNCA proteinShort-Term MemoryStriate BodyStriatumStructureSubstantia NigraSubstantia nigra structureSymptomsSyndromeTestingTherapeuticTremorVentral StriatumVentral Tegmental Areaa-syna-synucleinadult youthadvanced ageadvanced age ratsage associatedage associated neurodegenerationage associated neurodegenerative diseaseage associated neurodegenerative disorderage correlatedage dependentage dependent neurodegenerationage dependent neurodegenerative conditionage dependent neurodegenerative diseaseage dependent neurodegenerative disorderage linkedage relatedage related neurodegenerationage specificage-driven neurodegenerative disordersage-related neurodegenerative diseaseage-related neurodegenerative disorderagedaged rataged ratsagesaging associated neurodegenerationaging associated neurodegenerative diseaseaging related neurodegenerationaging related neurodegenerative diseaseaging related neurodegenerative disorderalpha synucleinalpha synuclein genealphaSP22alzheimer modelasynattenuateattenuatesbehavior influencebehavior mechanismbehavioral assessmentbehavioral influencebio-markersbiologic markerbiomarkercognitive assessmentcognitive defectscognitive dysfunctioncognitive functioncognitive losscognitive testingdementia in PDdementia in Parkinson diseasedepressionearly onseteffective therapyeffective treatmentefficacious therapyefficacious treatmentelderly ratsexperimentexperimental researchexperimental studyexperimentsfMRIgeriatricgeriatric ratsimaging biomarkerimaging markerimaging-based biological markerimaging-based biomarkerimaging-based markerimprovedinsoluble aggregatemodel of animalmotor diseasemotor disordermotor dysfunctionmotor symptommouse modelmultisensorymurine modelnatural agingnetwork dysfunctionneural controlneural degenerationneural imagingneural mechanismneural networkneural patterningneural regulationneuro-imagingneurobehavioral symptomneurodegenerationneurodegenerativeneuroimagingneurological degenerationneurological imagingneuromechanismneuromodulationneuromodulatoryneuronal degenerationneuropathologicneuropathologicalneuropathologyneuropsychiatricneuropsychiatryneuroregulationnon A-beta component of AD amyloidnon A4 component of amyloid precursornon-motor symptomnonmotor symptomnormal agingnormative agingold ratspathophysiologypatient living with Alzheimer's diseasepatient suffering from Alzheimer's diseasepatient with Alzheimer'spatient with Alzheimer's diseasepre-clinical researchpre-formed fibrilpreclinical researchprimary degenerative dementiaprogramsprotein aggregateprotein aggregationpublic health relevancesenile dementia of the Alzheimer typesenior citizensocial rolestriatalsynucleinsynucleinopathyventral tegmentumworking memoryyoung adultyoung adult ageyoung adulthoodα synuclein geneα-synα-synuclein

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Synucleinopathies such as Lewy body dementia (LBD) and Parkinson’s disease dementia (PDD), both Alzheimer’s disease-related disorders (ADRD), are some of the most common and fastest growing types of dementia in the world. In addition, synuclein pathology is increasingly appreciated as contributing to mixed pathology in dementias such as…

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