grant
Clustered protocadherin regulation of cortical interneuron survival circuit assembly and plasticity
Organization UNIVERSITY OF CALIFORNIA, SAN FRANCISCOLocation SAN FRANCISCO, UNITED STATESPosted 17 Sept 2020Deadline 31 Aug 2026
NIHUS FederalResearch GrantFY20242-photon21+ years oldAbscissionAdhesion MoleculeAdultAdult HumanAffectApoptosisApoptosis PathwayBrainBrain Nervous SystemBypassCalciumCell Adhesion Molecule GeneCell Adhesion MoleculesCell BodyCell Communication and SignalingCell DeathCell SignalingCellsCerebral cortexCodeCoding SystemCognitionConnector NeuronDataDevelopmentDysfunctionElectrophysiologyElectrophysiology (science)ElementsEncephalonEsthesiaExcisionExtirpationFamilyFore-BrainForebrainFunctional disorderGene ClusterGeneHomologGenetic AlterationGenetic ChangeGenetic defectGoalsHomologHomologous GeneHomologueImageImpairmentIn VitroIntercalary NeuronIntercalated NeuronsInterneuronsInternuncial CellInternuncial NeuronIntracellular Communication and SignalingIsoformsLifeLinkMedialMediatingMedulla SpinalisMental disordersMental health disordersMiceMice MammalsMicroelectrodesMiniaturized ElectrodesMorphologyMurineMusMutant Strains MiceMutationNeocortexNerve CellsNerve UnitNervous SystemNeural CellNeurocyteNeurologic Body SystemNeurologic Organ SystemNeuronsNeurophysiology / ElectrophysiologyPatternPhysiopathologyProcessProgrammed Cell DeathProsencephalonProtein IsoformsPsychiatric DiseasePsychiatric DisorderPyramidal CellsPyramidal neuronRegulationRemovalResolutionRetinaRoleSensationSignal TransductionSignal Transduction SystemsSignalingSliceSpinal CordSurgical RemovalSystemTestingTransfectionTransplantationabnormal brain functionadulthoodbiological signal transductionbrain dysfunctionbrain impairmentcell adhesion proteincombinatorialconditional knock-outconditional knockoutcritical perioddevelopmentaldysfunctional brainelectrophysiologicalgenome mutationhippocampal pyramidal neuronhomotypical corteximagingin vivoisocortexmental illnessmigrationmouse mutantmutantnecrocytosisneopalliumneural circuitneural circuitryneurocircuitryneuronalneuronal survivalpathophysiologypost-natal developmentpostnatalpostnatal developmentpsychiatric illnesspsychological disorderresectionresolutionssocial rolesynaptic circuitsynaptic circuitrytransplanttwo-photonvisual cortical plasticityvisual informationvisual plasticity
Full Description
Grant Number: 5R01MH122478-05
NIH Institute/Center: NIH
Principal Investigator: Arturo Alvarez-Buylla
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