grant
Clinical production of viral vectors for cancer gene therapy
Organization DIVISION OF BASIC SCIENCES - NCILocation UNITED STATES
NIHUS FederalResearch GrantFY2025AirAutologousBreast CancerCancer GenesCancer-Promoting GeneCategoriesCell BodyCell IsolationCell SegregationCell SeparationCell Separation TechnologyCellsClinicClinicalClinical ProtocolsColon CancerColon CarcinomaCore FacilityCoupledDNA TherapyDNA mutationDedicationsEcologic MonitoringEcological MonitoringEnsureEnvironmental MonitoringEpithelial CellsGene DeliveryGene ModifiedGene Transfer ClinicalGenerationsGenetic ChangeGenetic InterventionGenetic defectGenetic mutationGoalsGood Manufacturing ProcessGood manufacturing practiceHealth Care FacilityHealth FacilitiesHumidityIndividualInterruptionLaboratoriesLentiviral VectorLentivirus VectorMHC ReceptorMajor Histocompatibility Complex ReceptorMalignant Breast NeoplasmMalignant CellMalignant Tumor of the LungMalignant neoplasm of lungMechanicsMediatingMelanoma MetastasisMetastatic MelanomaMutationOncogenesOperative ProceduresOperative Surgical ProceduresPBMCPatientsPeripheral Blood LymphocytePeripheral Blood Mononuclear CellPhaseProductionProtocolProtocols documentationPulmonary CancerPulmonary malignant NeoplasmReagentReportingResearchRetroviral VectorRetrovirus VectorRiskRunningScheduleSolid NeoplasmSolid TumorSpecific qualifier valueSpecifiedSurgicalSurgical InterventionsSurgical ProcedureT cell based immune therapyT cell based therapeuticsT cell based therapyT cell directed therapiesT cell immune therapyT cell immunotherapyT cell receptor based immunotherapyT cell receptor cellular immunotherapyT cell receptor engineered therapyT cell receptor immunotherapyT cell targeted therapeuticsT cell therapyT cell treatmentT cell-based immunotherapyT cell-based treatmentT cellular immunotherapyT cellular therapyT lymphocyte based immunotherapyT lymphocyte based therapyT lymphocyte therapeuticT lymphocyte treatmentT-Cell Antigen ReceptorsT-Cell ReceptorT-Cell Receptor TherapyT-Cell Receptor TreatmentT-Cell Receptor based TherapyT-Cell Receptor based TreatmentT-CellsT-LymphocyteT-cell therapeuticsT-cell transfer therapyTCR T cell immunotherapyTCR T cell therapyTCR TherapyTCR based T cell immunotherapyTCR based TherapyTCR based immune therapyTCR based immunotherapyTCR based treatmentTCR immunotherapyTemperatureTestingTimeTransforming GenesTransgenesTumor-Infiltrating LymphocytesViralViral VectorVirusadoptive T cell transferadoptive T lymphocyte transferadoptive T-cell therapyantigen-specific T cellscancer cellcancer in the coloncare facilitiescell bankcell sortingcell transductioncellular transductionclinical lotcostcustomized therapycustomized treatmentenvironmental testingfirst in manfirst-in-humangene modificationgene repair therapygene therapygene therapy clinical trialgene-based therapygenetic therapygenetically modifiedgenome mutationgenomic therapyimprovedindividualized medicineindividualized patient treatmentindividualized therapeutic strategyindividualized therapyindividualized treatmentlung cancermalignant breast tumormanufacturemechanicmechanicalmeetingmeetingsneo-antigenneo-epitopesneoantigensneoepitopesnew approachesnovelnovel approachesnovel strategiesnovel strategyoperationoperationspatient specific therapiespatient specific treatmentphase 2 trialphase II trialpressureprogramsrepairrepairedsurgerytailored medical treatmenttailored therapytailored treatmenttherapeutic T-cell platformthymus derived lymphocytetransduced cellstransgenetrendtumorunique treatmentvector
Description preview
The Surgery Branch Vector Production Facility (SBVPF) was established to provide clinical-grade retroviral and lentiviral vectors to support of gene therapy clinical trials in the Branch with the primary goal of providing clinical grade products while reducing production time and cost. These products, both gamma-retroviral and lentiviral vectors…
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