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Claustrum serotonin and spike-timing plasticity associated with cognitive deficits after cocaine
Organization UNIVERSITY OF KENTUCKYLocation LEXINGTON, UNITED STATESPosted 1 Nov 2023Deadline 31 Mar 2025 ⚠️
NIHUS FederalResearch GrantFY20255-HT5-HT Agonists5-HT(2A) Receptor5-HT2A Receptor5-Hydroxytryptamine5-Hydroxytryptamine Agonists5-Hydroxytrytamine Agonist5HTAgonistAnimalsAnteriorAreaAttenuatedBehaviorBehavioralBilateralBrainBrain Nervous SystemCell BodyCell Communication and SignalingCell SignalingCellsCentral LobeCerebral DominanceClaustral structureClaustrumCocaineCognitiveCognitive deficitsCommon Rat StrainsDataDrug RegulationsDrug usageDrugsElectrophysiologyElectrophysiology (science)EncephalonEnteramineExcitatory SynapseFunctional MRIFunctional Magnetic Resonance ImagingGeneticGlutamatesGoalsHabitsHallucinogenic AgentsHallucinogenic DrugsHallucinogenic SubstancesHallucinogensHippophaineHistoryHumanImageIndividualInsulaInsula of ReilIntracellular Communication and SignalingInvestigationIsland of ReilL-GlutamateLinkLiteratureLong-Term DepressionLong-Term PotentiationLong-Term Synaptic DepressionMajor Depressive DisorderMediatingMediatorMedicationMental disordersMental health disordersMicroinjectionsModelingModern ManModificationNerve CellsNerve Impulse TransmissionNerve TransmissionNerve UnitNeural CellNeurocyteNeuronal TransmissionNeuronsNeurophysiology / ElectrophysiologyOutputPatientsPatternPharmaceutical PreparationsPicrotoxinProtocolProtocols documentationPsychedelic AgentsPsychedelicsPsychiatric DiseasePsychiatric DisorderPsychotomimetic AgentsRatRats MammalsRattusReceptor ProteinRecording of previous eventsRegulationRelapseResearchRoleSalineSaline SolutionScientistSerotonergic AgonistsSerotoninSerotonin 2A ReceptorSerotonin AgonistsSerotonin Receptor 5-HT2ASerotonin Receptor AgonistsSignal TransductionSignal Transduction SystemsSignalingSliceStructureSubstance Use DisorderSubstance abuse problemSymptomsSynapsesSynapticSynaptic plasticityTask PerformancesTestingTherapeuticTrainingWithdrawalabuse of substancesabused drugabused drugsantagonismantagonistattenuateattenuatesaxon signalingaxon-glial signalingaxonal signalingbehavior phenotypebehavioral phenotypingbiological signal transductionbrain lateralitycareer developmentcerebral lateralizationcingulate cortexclinical depressioncocaine exposurecocaine seekingcocaine self-administrationcocaine usecocaine-exposedcognitive defectsdensitydrug abuseddrug developmentdrug of abusedrug relapsedrug seeking behaviordrug usedrug/agentdrugs abuseddrugs of abuseelectrophysiologicalexperienceexperimentexperimental researchexperimental studyexperimentsexposed to cocaineexposure to cocainefMRIflexibilityflexibleglia signalingglial signalingglutamate signalingglutamatergicglutamatergic dendrodendritic synapsesglutamatergic signalinghemispheric specializationhistoriesimagingimprovedin vivoin vivo Modelinnervationmajor depressionmajor depression disordermental illnessnerve signalingnerve supplyneural signalingneuronalneuronal signalingneurotransmissionnovelpatch clamppsychedelic drugpsychiatric illnesspsychological disorderpsychotomimetic drugputamenreceptorself-administer cocainesocial rolesubstance abusesubstance usesubstance use and disordersubstance usersubstance usingsynapsesynapse inhibitionsynaptic inhibition
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Project Summary/Abstract
Over 40 million individuals in the US have a substance use disorder (SUD), and therapies for treating SUD have
remained largely inadequate for decades. One of the key challenges in SUD treatment is that many drugs of
abuse, including cocaine, negatively impact cognitive flexibility, leaving patients less likely to abstain…
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