grant

Circuit control of motivation to take and seek alcohol

Organization VANDERBILT UNIVERSITYLocation Nashville, UNITED STATESPosted 10 Jul 2023Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY2025AMPA ReceptorsAbstinenceAcuteAddressAffectiveAlcohol Chemical ClassAlcohol DrinkingAlcohol consumptionAlcohol withdrawal syndromeAlcoholsAmygdalaAmygdaloid BodyAmygdaloid NucleusAmygdaloid structureAnimalsAversive StimulusBehaviorBehavioralBrainBrain Nervous SystemBrain regionCell BodyCell Communication and SignalingCell SignalingCellsChronicConsumptionCuesDataDevelopmentDiseaseDisorderDrug usageETOH levelElectrophysiologyElectrophysiology (science)EncephalonEndoscopyEtOH drinkingEtOH useGlutamatesGoalsHistoryIndividualInhalationInhalingIntracellular Communication and SignalingL-GlutamateLearningLinkMapsMarbleMeasuresMiceMice MammalsModelingMotivationMurineMusNegative ReinforcementsNerve CellsNerve UnitNeural CellNeurocyteNeuronsNeurophysiology / ElectrophysiologyNucleus AccumbensOpticsPatternPhysiologicPhysiologicalPlayPopulationPopulation ControlPositive ReinforcementsPrefrontal CortexPrevalencePsychological reinforcementRecording of previous eventsReinforcementResearchResolutionRoleSelf AdministeredSelf AdministrationSignal TransductionSignal Transduction SystemsSignalingSliceSystemThalamic structureThalamusWithdrawalWithdrawal SymptomWorkaffective disturbancealcohol cuealcohol exposedalcohol exposurealcohol ingestionalcohol intakealcohol levelalcohol measurementalcohol product usealcohol reinforcementalcohol related cuealcohol responsealcohol seekingalcohol seeking behavioralcohol usealcohol use disorderalcohol withdrawalalcoholic beverage consumptionalcoholic drink intakeamygdaloid nuclear complexawakebiological signal transductionbrain controlcell typecostdevelopmentaldisturbance in affectdrinkingdrug useelectrophysiologicalendoscopic imagingethanol consumptionethanol cueethanol drinkingethanol exposedethanol exposureethanol ingestionethanol intakeethanol measurementethanol product useethanol reinforcementethanol responseethanol seekingethanol useethanol use disorderethanol withdrawalethanol-seeking behaviorethyl alcohol measurementsexposed to alcoholexposed to ethanolexposure to alcoholexposure to ethanolfeedingglutamatergichistoriesin vivomaladaptive behaviormood alterationmood and affect disturbancemood disturbancemood dysfunctionmotivated behaviornegative affectnegative affectivityneuralneural circuitneural circuitryneurocircuitryneuronalopticaloptogeneticspatch clamppreventprevent relapsepreventingreinforcerrelapse preventionresolutionsresponse to alcoholresponse to ethanolsocial rolesynaptic circuitsynaptic circuitrythalamictreatment strategyvaporwithdrawal from alcohol
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ABSTRACT
Alcohol Use disorder (AUD) is a disorder in which alcohol alters a wide range of neural circuits to cause

maladaptive behaviors across several behavioral domains. Despite the prevalence and cost of this disorder,

treatment strategies are ineffective, especially in preventing relapse. A key feature in some individuals is the

induction of…

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Circuit control of motivation to take and seek alcohol — VANDERBILT UNIVERSITY | UNITED STATES | Jul 2023 | Dev Procure