grant
Circadian regulation of mitochondrial function by muscle RORs to promote healthy aging
Organization UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTONLocation HOUSTON, UNITED STATESPosted 15 Sept 2024Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY202521+ years old3-D3-Dimensional3DAcidsAdultAdult HumanAgeAgingAgonistArchitectureAssayAutoregulationBehavioralBioassayBioenergeticsBiologicalBiological AssayBody TissuesBody WeightCRISPRCRISPR/Cas systemChIP SequencingChIP assayChIP-seqChIPseqCircadian DysregulationCircadian RhythmsClustered Regularly Interspaced Short Palindromic RepeatsComplexCyclicityDeteriorationDevelopmentDiseaseDisorderEatingElderlyEmbryonic Muscle CellsEngineering / ArchitectureEnhancersEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessExerciseExercise ToleranceFc ReceptorFood IntakeGene Action RegulationGene ExpressionGene Expression RegulationGene RegulationGene Regulation ProcessGene TranscriptionGenesGeneticGenetic TranscriptionGenomeGenomicsGrip strengthHand StrengthHealthHealth PromotionHi-CHistonesHomeostasisHumanImpairmentIncrease lifespanIntermediary MetabolismInterventionIntervention StrategiesIntervention StudiesInvestigatorsKO miceKnock-outKnock-out MiceKnockoutKnockout MiceKnowledgeLXR-alpha proteinLXRA gene productLXRalphaLXRalpha proteinLXRαLife StyleLifestyleLong-Term EffectsMetabolicMetabolic ProcessesMetabolismMethodologyMiceMice MammalsMitochondriaModern ManModernizationMolecularMolecular AnalysisMurineMusMuscleMuscle FibersMuscle MitochondriaMuscle TissueMuscle functionMyoblastsMyotubesNuclear ReceptorsNull MouseNyctohemeral RhythmOrphanPeriodicityPharmacological StudyPharmacology StudyPhasePhysiologicPhysiologicalPhysiological HomeostasisPhysiologyPlayPopulationPrecursor Muscle CellsProductionPublic HealthQOL improvementRNA ExpressionReceptor ProteinRecordsRegulationReporterResearch PersonnelResearchersRespirationRetinoic Acid AgentRetinoic Acid and DerivativesRetinoidsRhabdomyocyteRhythmicityRoleRunningSalutogenesisSarcosomesSkeletal FiberSkeletal MuscleSkeletal Muscle CellSkeletal Muscle FiberSkeletal MyocytesSleepSocietiesSurvival AnalysesSurvival AnalysisTimeTissuesTranscriptionTwenty-Four Hour RhythmVoluntary Muscleadulthoodadvanced ageage associatedage associated declineage correlatedage dependentage dependent declineage linkedage relatedage related declineage specificagedaged groupaged groupsaged individualaged individualsaged miceaged mouseaged muscleaged peopleaged personaged personsaged populationaged populationsagesaging associatedaging delayaging of muscleaging populationaging relatedantibody receptorattenuate agingbiologicboost longevitychromatin immunoprecipitationchromatin immunoprecipitation coupled with sequencingchromatin immunoprecipitation followed by sequencingchromatin immunoprecipitation with sequencingchromatin immunoprecipitation-seqchromatin immunoprecipitation-sequencingcircadiancircadian abnormalitycircadian clockcircadian disruptioncircadian disturbancecircadian dysfunctioncircadian impairmentcircadian pacemakercircadian processcircadian regulationcircadian rhythmicitydaily biorhythmdecelerate agingdecline with agedelay age relateddevelopmentaldisease modeldisease riskdisorder modeldisorder riskelderly miceelongating the lifespanenhance healthspanenhance longevityepigenetic regulationepigeneticallyepigenomeexercise interventionextend healthspanextend life spanextend lifespanextend longevityextending healthy lifespanfitnessfoster longevitygain of functiongeriatrichealthspanhealthspan extensionhealthy aginghealthy human aginghealthy life spanhexamethoxyflavoneimprove healthspanimprove lifespanimprove longevityimprovedimprovements in QOLimprovements in quality of lifeincrease healthspaninnovateinnovationinnovativeinsightintervention researchinterventional researchinterventional studyinterventions researchlife spanlife style interventionlifespanlifespan extensionlifestyle interventionliver X receptor alphaliver X receptor αloss of functionmetabolic fitnessmid lifemid-lifemiddle agemiddle agedmidlifemitochondrialmitochondrial dysfunctionmitochondrial metabolismmuscle agingmuscularnobiletinnovelold miceorphan nuclear receptor LXR-alphaoxysterols receptor LXR-alphapause agingpharmacologicphysical activity interventionpopulation agingpostpone age relatedprolong healthspanprolong lifespanprolong longevitypromote healthspanpromote lifespanpromote longevitypromoterpromoting healthpromotorquality of life improvementreceptorrespiratoryrespiratory mechanismretards agingsenior citizenskeletal muscle metabolismskeletal muscle protein metabolismslow agingslow down agingslow the rate of agingsocial rolesupport longevitythree dimensionaltranscriptomicstranslational impact
Description preview
PROJECT SUMMARY / ABSTRACT
A fundamental challenge in our rapidly aging society is how to extend healthspan, or maintain robust fitness
without major diseases. The circadian clock, our intrinsic timer, is a pivotal cellular mechanism to promote health
and healthy aging, as both loss- and gain-of-function studies have provided strong experimental…
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