grant
Circadian Regulation of Cardiomyocyte Size and Function
Organization UNIVERSITY OF KENTUCKYLocation LEXINGTON, UNITED STATESPosted 1 Jan 2025Deadline 31 Dec 2029
NIHUS FederalResearch GrantFY202521+ years oldARNTLARNTL geneATAC sequencingATAC-seqATACseqAccelerationAddressAdultAdult HumanAffectAnimalsArrhythmiaAssay for Transposase-Accessible Chromatin using sequencingAsymmetric Septal HypertrophyBMAL1BehaviorBiological ClocksCardiac AbnormalitiesCardiac ArrhythmiaCardiac Muscle CellsCardiac MyocytesCardiac beta-MyosinCardiac healthCardiac infarctionCardiocyteCell BodyCell DifferentiationCell Differentiation processCell FunctionCell PhysiologyCell ProcessCell SizeCell modelCellsCellular ExpansionCellular FunctionCellular GrowthCellular PhysiologyCellular ProcessCellular modelChIP SequencingChIP-seqChIPseqCircadian DysregulationCircadian RhythmsColeonolCommunicationDNA mutationDataDevelopmentDiseaseDisorderDrug ScreeningDysfunctionES cellEnvironmentForskolinFunctional disorderGeneralized GrowthGenesGeneticGenetic ChangeGenetic defectGenetic mutationGrowthHeartHeart AbnormalitiesHeart ArrhythmiasHeart HypertrophyHeart Muscle CellsHeart healthHeart myocyteHereditaryHereditary DiseaseHereditary ventricular hypertrophyHypertrophic CardiomyopathyHypertrophic Obstructive CardiomyopathyHypertrophyIdiopathic Hypertrophic Subvalvular StenosisIdiopathic hypertrophic subaortic stenosisIn VitroInborn Genetic DiseasesInheritedInherited disorderInterventionJet LagJet Lag SyndromeJetlagJetlag SyndromeKnock-outKnockoutKnowledgeMentorsMiceMice MammalsModelingMurineMusMutationMyocardial InfarctMyocardial InfarctionMyocardial depressionMyocardial dysfunctionMyocardiumMyosin V3Nyctohemeral RhythmOrganPace StimulatorsPacemakersPeripheralPhysiologicPhysiologicalPhysiologyPhysiopathologyProgenitor CellsProteinsRNA SeqRNA sequencingRNAseqRegulationResearchSarcomeresSleep disturbancesStimulusSubcellular ProcessTechniquesTemperatureTimeTime Zone Change SyndromeTime Zone SyndromeTissue GrowthTraction Force MicroscopyTrainingTwenty-Four Hour RhythmVentricular Cardiac beta-MyosinVentricular beta-MyosinWorkaberrant sleepadulthoodage associatedage correlatedage dependentage linkedage relatedage specificaryl hydrocarbon receptor nuclear translocator-likeassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingbeta-Myosinbody clockcardiac dysfunctioncardiac hypertrophycardiac infarctcardiac musclecardiac myocytes differentiated from induced pluripotent stem cellcardiomyocytecareercell growthcell typecellular differentiationchromatin immunoprecipitation coupled with sequencingchromatin immunoprecipitation followed by sequencingchromatin immunoprecipitation with sequencingchromatin immunoprecipitation-seqchromatin immunoprecipitation-sequencingcircadian abnormalitycircadian clockcircadian disruptioncircadian disturbancecircadian dysfunctioncircadian impairmentcircadian pacemakercircadian processcircadian regulationcircadian rhythmicitycoronary attackcoronary infarctcoronary infarctiondaily biorhythmday shiftdevelop therapydevelopmentaldisrupted sleepdisturbed sleepembryo derived stem cellembryonal stem cellsembryonic progenitorembryonic stem cellfamilial cardiomyopathygenetic cardiomyopathygenome mutationheart attackheart dysfunctionheart infarctheart infarctionheart musclehereditary cardiomyopathyhereditary disorderheritable disorderhiPSChuman iPShuman iPSChuman induced pluripotent cellhuman induced pluripotent stem cellshuman inducible pluripotent stem cellshuman inducible stem cellshypertrophic myocardiopathyiPS cell derived cardiomyocytesiPSC derived cardiomyocytesimpaired sleepinborn errorinduced human pluripotent stem cellsinduced pluripotent stem cell derived cardiac myocytesinduced pluripotent stem cell derived cardiomyocytesinducible pluripotent stem cell derived cardiac myocytesinducible pluripotent stem cells derived cardiomyocytesinherited cardiomyopathyinherited diseasesinherited genetic diseaseinherited genetic disorderinsightinternal clockintervention developmentirregular sleepnight shiftnight workontogenyoverexpressoverexpressionpathophysiologyshift workshiftworksleep disruptionsleep dysregulationsleep/wake disruptionsleep/wake disturbancestemstem cell of embryonic originstem cellssuprachiasmatic nucleustherapy developmenttranscriptome sequencingtranscriptomic sequencingtranscriptomicstreatment developmentβ-Myosin
Get Agency plan to apply$29.99/mo · 7-day free trial · pipeline · alerts
or
— or —Get email alerts for similar roles
Description preview
PROJECT SUMMARY
The overall objectives of this study are to 1) establish hiPSC-CMs as robust models for mechanistic studies of
how intrinsic circadian regulation impacts cardiomyocyte size and function and 2) determine whether mutations
that impact cellular size and function also disrupt cardiomyocyte clock rhythms.
In the heart, disruptions in…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click