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Cilia in Heart Development and Disease
Organization YALE UNIVERSITYLocation NEW HAVEN, UNITED STATESPosted 15 Feb 2019Deadline 31 Jan 2026 ⚠️
NIHUS FederalResearch GrantFY202521+ years oldAddressAdultAdult HumanAffectBiologicalBirth DefectsBrachydanio rerioCandidate Disease GeneCandidate GeneCardiacCardiac DiseasesCardiac DisordersCardiac MalformationCardiac ValvesCardiac developmentCausalityCell BodyCell Communication and SignalingCell SignalingCellsCiliaClinicalClinical ResearchClinical StudyCongenital AbnormalityCongenital Anatomical AbnormalityCongenital DefectsCongenital DeformityCongenital MalformationContracting OpportunitiesContractsDNA mutationDanio rerioDataDevelopmentDysfunctionEmbryoEmbryonicEnvironmentEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEtiologyFunctional disorderGene TranscriptionGenesGeneticGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationGenomicsGoalsHeartHeart DiseasesHeart MalformationHeart ValvesHistone H2BHumanInfantIntracellular Communication and SignalingInvestigatorsLeadLeftLinkMiceMice MammalsModern ManMolecularMonoubiquitinationMorphogenesisMurineMusMutationOrganOutcomePatientsPb elementPediatric Cardiac Genomics ConsortiumPhysiopathologyPublic HealthRNA ExpressionResearch PersonnelResearchersRoleSignal TransductionSignal Transduction SystemsSignalingSpecific qualifier valueSpecifiedStructureTestingTranscriptionTranslatingWorkZebra DanioZebra FishZebrafishabnormal heart developmentadulthoodbiologicbiological signal transductioncardiac myocytes differentiated from induced pluripotent stem cellcardiogenesiscausationchromatin remodelingco-morbidco-morbiditycohortcomorbiditycongenital cardiac abnormalitycongenital cardiac anomaliescongenital cardiac diseasecongenital cardiac disordercongenital cardiac malformationcongenital heart abnormalitycongenital heart anomalycongenital heart diseasecongenital heart disordercongenital heart malformationdevelopmentaldisease causationepigeneticallyexperimentexperimental researchexperimental studyexperimentsextracellulargenome mutationgenomic datagenomic datasetheart developmentheart disorderheart formationheavy metal Pbheavy metal leadhiPSChuman iPShuman iPSChuman induced pluripotent cellhuman induced pluripotent stem cellshuman inducible pluripotent stem cellshuman inducible stem cellsiPS cell derived cardiomyocytesiPSC derived cardiomyocytesimprovedinduced human pluripotent stem cellsinduced pluripotent stem cell derived cardiac myocytesinduced pluripotent stem cell derived cardiomyocytesinducible pluripotent stem cell derived cardiac myocytesinducible pluripotent stem cells derived cardiomyocyteslive cell imagelive cell imaginglive cellular imagelive cellular imagingmechanical drivemechanical forcemorphogenetic processmouse developmentoptogeneticspathophysiologypersonalization of treatmentpersonalized medicinepersonalized therapypersonalized treatmentscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolezebrafish development
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Description preview
Congenital Heart Disease (CHD) is the most common birth defect affecting 1% of all live born infants. While
~90% of patients with CHD survive into adulthood, there are many comorbidities that make CHD an
increasingly significant public health problem. Genomic analyses of large cohorts of CHD patients have
identified a significant genetic…
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