grant
Chromosome-specific meiotic biology
Organization UNIVERSITY OF GEORGIALocation ATHENS, UNITED STATESPosted 1 Sept 2025Deadline 31 Aug 2030
NIHUS FederalResearch GrantFY2025AneuploidAneuploidyBehaviorBiologicalBiologyBirth DefectsCannot achieve a pregnancyCell BodyCellsChromosomal OrganizationChromosomal StructureChromosome OrganizationChromosome SegregationChromosome StructuresChromosomesCongenital AbnormalityCongenital Anatomical AbnormalityCongenital DefectsCongenital DeformityCongenital MalformationCrossing OverDNA RecombinationDNA crossoverDefectDevelopmentDifficulty conceivingDiploidDiploidyDrosophila melanogasterEventExhibitsFertility DisordersGametesGenetic Crossing OverGenetic RecombinationGenomeGerm CellsGerm-Line CellsGoalsHaploidHaploidyIndividualInfertilityLocationMeiosisModelingMolecularOrganismOutcomePositionPositioning AttributeProcessRecombinationRegulationReproductive CellsSex CellSpermSpermatozoaStructureSynaptonemal ComplexWorkX Chromosomeautosomebiologicchromosomal missegregationchromosome divisionchromosome missegregationcrossover recombinationdevelopmentaleggfertility cessationfertility defectfertility lossgenomic crossoverinfertileinitial cellinsightinter-homolog crossoverliving systemloss of functionmeioticmeiotic crossovermutantnon-sister chromatid exchangenonsister chromatid exchangesegregationsexual cellsperm cellzoosperm
Description preview
Project Summary (30 lines)
Meiosis is a tightly controlled process during which the diploid genome must segregate into haploid gametes
(e.g. eggs or sperm). Inheritance of the incorrect number of chromosomes is a leading cause of fertility and
birth defects. However, the reasons for chromosome missegregation are not always the same for all…
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