grant
Chromatin Regulation in Brain Development and Disease
Organization DIVISION OF BASIC SCIENCES - NCILocation UNITED STATES
NIHUS FederalResearch GrantFY2025BindingBinding ProteinsBrainBrain Nervous SystemCancersCell divisionCerebroatrophic HyperammonemiaChromatinDNADNA DamageDNA InjuryDNA MethylationDNA SequenceDNA methyltransferase 3 alpha mutationDNA mutationDNMT3aDNMT3a mutationDeoxyribonucleic AcidDevelopmentDiseaseDisorderEncephalonEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessFaceGene ExpressionGenetic ChangeGenetic defectGenetic mutationGenomeGenomic approachGoalsLeadLearningLigand Binding ProteinLigand Binding Protein GeneMalignant NeoplasmsMalignant TumorMeCP-2 proteinMeCP2MeCP2 proteinMemoryMethyl CpG binding protein MeCP2Methyl-CpG-Binding Protein 2Methyl-DNA binding protein MECP2MethylationModificationMolecularMolecular InteractionMutateMutationNerve CellsNerve UnitNeural CellNeurocyteNeurodevelopmental DisorderNeurological Development DisorderNeuronsOrganismPb elementProtein BindingProteinsR-Series Research ProjectsR01 MechanismR01 ProgramReaderRegulationResearchResearch GrantsResearch Project GrantsResearch ProjectsRett DisorderRett SyndromeRoleSyndromebound proteincell typedevelopmentalepigeneticallyexperimentexperimental researchexperimental studyexperimentsfacesfacialgenome integritygenome mutationgenomic effortgenomic integritygenomic strategyhDNA methyltransferase 3aheavy metal Pbheavy metal leadinsightlife spanlifespanliving systemloss of function mutationmalignancyneoplasm/cancerneurodevelopmental diseaseneuronaloverexpressoverexpressionpostnatalsocial role
Description preview
During FY2025, we made significant progress on this research project studying chromatin and epigenetics in brain development and how mutations in chromatin regulators lead to neurodevelopmental disorders and cancer. In one part of the research project, we are using molecular and genomic approaches to understand the function of a neuron-enriched…
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