grant
Chromatin contacts are germline-transmissable vehicles underlying epigenetic transgenerational inheritance
Organization UNIVERSITY OF CALIFORNIA-IRVINELocation IRVINE, UNITED STATESPosted 1 Sept 2013Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY202621+ years oldAdipocytesAdipose CellAdultAdult HumanAdult-Onset Diabetes MellitusAffectAnimal ModelAnimal Models and Related StudiesAnimalsAppetiteAutomobile DrivingBiologicalBiologyCRISPRCRISPR/Cas systemCausalityCell CountCell IsolationCell NumberCell SegregationCell SeparationCell Separation TechnologyChIP SequencingChIP-seqChIPseqChemical ExposureChemicalsChromatinChromatin Structure AlterationClinicalClustered Regularly Interspaced Short Palindromic RepeatsConsumptionDNADNA mutationDNA-Binding ProteinsDataDeoxyribonucleic AcidDesire for foodDietDietary FatsDiseaseDisorderDoseEmbryoEmbryonicEndocrine DisrupterEndocrine Disrupting ChemicalsEndocrine DisruptorsEndocrine disrupting agentEnvironmentEnvironmental ExposureEnvironmental FactorEnvironmental Risk FactorEnzyme GeneEnzymesEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEtiologyExperimental DesignsExperimental ModelsExposure toFastingFat CellsFat-Restricted DietFatsFatty acid glycerol estersFutureFuture GenerationsGene ExpressionGenerationsGenetic ChangeGenetic defectGenetic mutationGerm LinesGestationGoalsHealthHealth Care CostsHealth CostsHereditaryHi-CHigher Order Chromatin FoldingHigher Order Chromatin StructureHigher Order StructureHumanHyperglycemiaHyperinsulinemiaHyperinsulinismInheritedInsulin ProteaseInsulin ProteinaseInsulin ResistanceInsulin-Degrading EnzymeInsulinaseInsulysinIntermediary MetabolismInterventionKO miceKetosis-Resistant Diabetes MellitusKnock-out MiceKnockout MiceLactationLinkLipocytesLiteratureLiverLow-Fat DietMature LipocyteMature fat cellMaturity-Onset Diabetes MellitusMemoryMessenger RNAMetabolic DiseasesMetabolic DisorderMetabolic ProcessesMetabolismMiceMice MammalsModelingModern ManMolecularMurineMusMutationNIDDMNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusNuclear ProteinsNuclear ReceptorsNull MouseObesityOnset of illnessOutcomePhenocopyPhenotypePlayPredispositionPregnancyPreventionPrimordial Germ CellProductivityPublic HealthPublishingRepressionReproducibilityResearchResistanceRisk AssessmentRodentRodentiaRodents MammalsRoleSatiationSeriesSlow-Onset Diabetes MellitusStable Diabetes MellitusStructure of primordial sex cellSusceptibilityT2 DMT2DT2DMTechniquesTechnologyTestingThesaurismosisTransmissionType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesadiposityadult adiposityadult obesityadult onset diabetesadulthoodadults with obesitybiologicbisphenol Acausationcell sortingchromatin immunoprecipitation coupled with sequencingchromatin immunoprecipitation followed by sequencingchromatin immunoprecipitation with sequencingchromatin immunoprecipitation-seqchromatin immunoprecipitation-sequencingcommunicable disease transmissioncorpulencedesigndesigningdietary lipiddietsdiphenylolpropanedisease causationdisease onsetdisease transmissiondisorder onsetdrinking waterdrivingendocrine disrupting compoundenergy balanceenvironmental riskenvironmental stressesenvironmental stressorepigeneticallyepigenomicsexperimentexperimental researchexperimental studyexperimentsexposure to environmental agentsexposure to environmental factorsexposure to environmental stimuliexposure to environmental substancesfast weight gainfastedfastsfocus on malefocused on mengenome analysisgenome mutationhepatic body systemhepatic organ systemhormonal regulationhormone regulationhuman modelhyperglycemicinfectious disease transmissioninsightinsulin resistantinsulin toleranceketosis resistant diabeteslactatinglactationallater in lifelater lifemRNAmRNA Expressionmalemale focusedmale groupmale specificmale targetedmaturity onset diabetesmen's groupmetabolic phenotypemetabolism disordermetabotypemodel of animalmodel of humanmouse modelmultiomicsmultiple omicsmurine modelobesity preventionobesogenpandemicpandemic diseasepanomicsphthalatespregnantprenatalpreventprevent obesitypreventingrapid weight gainresistantresponsesatietysocial rolesudden weight gaintargeted to mentransgenerational epigenetic inheritancetransgenerational inheritancetransmission processtri-n-butyltintributylstannanetributyltintype 2 DMtype II DMtype two diabetesunborn♂
Description preview
Studies in animal models linked gestational exposures to endocrine disrupting chemicals (EDCs) with the
onset of disease in exposed and unexposed descendants. Many groups found such transgenerational effects
of chemical exposures, which were proposed to be examples of epigenetic inheritance. Transgenerational
effects of environmental exposures…
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