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Children's Oncology Group
Organization UNIVERSITY OF SOUTHERN CALIFORNIALocation Los Angeles, UNITED STATESPosted 1 Mar 2023Deadline 28 Feb 2026 ⚠️
NIHUS FederalResearch GrantFY20250-11 years old1 year of age1 year oldAML - Acute Myeloid LeukemiaAccelerationAcuteAcute Myeloblastic LeukemiaAcute Myelocytic LeukemiaAcute Myelogenous LeukemiaAdolescentAdolescent YouthAdverse Late EffectsAustraliaBiologyBody TissuesBrain Stem GliomaBrain Stem Neuroglial NeoplasmBrain Stem Neuroglial TumorBrainstem GliomaBrainstem Neuroglial NeoplasmBrainstem Neuroglial TumorCanadaCancer CenterCancer PatientCancer TreatmentCancersCaringCause of DeathCell TherapyChildChild SupportChild YouthChildhoodChildhood Cancer TreatmentChildhood CancersChildhood LeukemiaChildren (0-21)Children's HospitalChildren's Oncology GroupClinicalClinical Cooperative GroupsClinical ResearchClinical StudyClinical Trial GroupsClinical TrialsClinical Trials Cooperative GroupClinical Trials DesignCollaborationsCollectionCombination Drug TherapyCommunitiesCompanionsComplicationCountryDataData Management CoreDevelopmentDiagnosisDiseaseDisorderDoseDrugsDysfunctionEnsureFamilyFoundationsFunctional disorderGenerationsGoalsHormonalImmune mediated therapyImmunologically Directed TherapyImmunotherapyIndustryInfrastructureInstitutionInterdisciplinary ResearchInterdisciplinary StudyInvestigatorsKnowledgeLaboratoriesLate EffectsMalignant Childhood NeoplasmMalignant Childhood TumorMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant Pediatric NeoplasmMalignant Pediatric TumorMalignant TumorMalignant childhood cancerMedicationMethodsMissionMolecularMorbidityMorbidity - disease rateMultidisciplinary CollaborationMultidisciplinary ResearchNCI OrganizationNational Cancer InstituteNational Clinical Trials NetworkNeuroblastomaNew ZealandOrganOrganization ChartsOrphan DiseaseOutcomePatientsPediatric Cancer TreatmentPediatric HospitalsPediatric LeukemiaPediatric Oncology GroupPharmaceutical PreparationsPhysiopathologyPolychemotherapyPopulation HeterogeneityPopulation ResearchPopulation-based researchPopulation-level researchPrognosisQOLQOL improvementQuality of lifeRare DiseasesRare DisorderReportingResearchResearch PersonnelResearchersSaudi ArabiaScienceSecond CancerSecond Primary CancersSecondary MalignancySecondary Malignant NeoplasmSurvival RateSurvivorsTissuesTranslational ResearchTranslational ScienceUnited StatesUniversitiesWorkacute granulocytic leukemiaacute myeloid leukemiaage 1 yearaged 1 yearaged one yearanti-cancer researchanti-cancer therapycancer diagnosiscancer in a childcancer in childrencancer researchcancer therapycancer-directed therapycell based interventioncell mediated interventioncell mediated therapiescell-based therapeuticcell-based therapycellular therapeuticcellular therapychemotherapychild with cancerchildhood cancer survivorchildhood malignancychildren with leukemiaclinical translationclinically translatablecombination chemotherapycombination pharmacotherapydata managementdata management and coordinating centerdata management centerdata sharingdesigndesigningdevelopmentaldiverse populationsdrug/agentexperiencefunctional outcomeshealth related quality of lifeheterogeneous populationhigh riskimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyimprovedimproved outcomeimprovements in QOLimprovements in quality of lifeinnovateinnovationinnovativejuvenilejuvenile humankidsleukemia in childrenmalignancymembermortalitymultidisciplinaryneoplasm/cancernew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachone year of ageone year oldorganizational structureorphan disorderpathophysiologypediatricpediatric cancerpediatric cancer survivorpediatric malignancypopulation diversityprogramsquality of life improvementreproductivesecondary cancersmall moleculestatisticssurvivorshiptranslation researchtranslational clinical trialtranslational investigationtranslational investigatortranslational researchertranslational scientisttranslational studytrial designyoungster
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PROJECT SUMMARY
Since the introduction of combination chemotherapy for the treatment of childhood leukemia more than 60
years ago, the prognosis of childhood cancer has improved dramatically. The 5-year survival rate for childhood
cancers, many of which were uniformly fatal in the pre-chemotherapy era, is now over 85% for all forms of
childhood…
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