grant
CHEMISTRY, MANUFACTURING, AND CONTROLS (CMC) DEVELOPMENT OF NES-100 AS A NASAL SPRAY OF A NEW ANALGESIC
Organization LEIDOS BIOMEDICAL RESEARCH, INC.Location FREDERICK, UNITED STATESPosted 15 Sept 2025Deadline 14 Sept 2030
NIHUS FederalResearch GrantFY2025Analgesic AgentsAnalgesic DrugsAnalgesic PreparationAnalgesicsAnodynesAntinociceptive AgentsAntinociceptive DrugsAwardChemistryContracting OpportunitiesContractorContractsDataDevelopmentDevicesDosage FormsDrugsDrynessEquipmentExcipientsFormulationGasesHPLCHigh Performance Liquid ChromatographyHigh Pressure Liquid ChromatographyHigh Speed Liquid ChromatographyIND FilingIND applicationIND packageIND submissionInvestigational New Drug ApplicationMedicationMethodsNCATSNasalNasal Passages NoseNational Center for Advancing Translational SciencesNosePeptidesPharmaceutical PreparationsPowder dose formPowdersProcessRecordsRespiratory System, Nose, Nasal PassagesSafetySpecific qualifier valueSpecifiedTestingdevelopmentaldrug/agentinterestmanufacturenano particlenano-sized particlenanoparticlenanosized particlepain killerpain medicationpain relieverpainkillerparticlepressurepropellant
Description preview
This is to award the contract to perform all the tasks listed here. Offeror is referred to contractor/subcontractor hereafter.
NES100 is formulated by high pressure homogenization of MET and LENK to form nanoparticles, followed by spray drying to produce MET-LENK microparticles. The microparticle powder is then filled into a nasal device. The…
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