grant
Chemically Modified Peptide Nucleic Acids
Organization NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASESLocation UNITED STATES
NIHUS FederalResearch GrantFY2025AbbreviationsAffinityBase SequenceBindingBiologicalBiological TerrorismBioterrorBioterrorismCell BodyCellsChemicalsChemistryCouplingDNA SequenceDetectionDevelopmentDiseaseDisease MarkerDisorderEnzyme AntagonistEnzyme InhibitorEnzyme Inhibitor AgentEnzyme Inhibitor DrugsGeneralized GrowthGoalsGrowthLinkMalignant CellManuscriptsMethodsMicroRNAsModificationMolecular InteractionMonitorNon-Polyadenylated RNANucleotide SequencePenetrationPeptidesPropertyPublishingRNARNA Gene ProductsRNA SequencesReceptor ProteinResearchRibonucleic AcidSpecificityTechnologyTissue GrowthWorkbiologiccancer cellclinical diagnosticsdesigndesigningdetection assaydevelopmentaldiagnostic technologiesdisease diagnosticimprovedinterestinventionmedical diagnosticmiRNAnovelnucleic acid detectionnucleic acid sequenceontogenyoverexpressoverexpressionpathogenreceptorsmall molecular inhibitorsmall moleculesmall molecule inhibitortechnology platformtechnology systemtooluptake
Description preview
Our research on Peptide Nucleic Acids (abbreviated as PNAs) focuses on introducing chemical modifications that will make this class of molecules broadly useful to detect sequences of nucleic acids and also to inspire new types of small molecule inhibitors for enzymes. Unique nucleic acid sequences are associated with diseases, pathogens, and many…
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