grant
Chemical Proteomics Approach to Discover Novel Small Molecule E3 Ligase recruiters for Targeted Protein degradation (TPD)
NIHUS FederalResearch GrantFY2025Body TissuesChemicalsChemistryCoupledCysteineDevelopmentDiseaseDisorderE3 LigaseE3 Ubiquitin LigaseFK506-Binding Protein 1FK506-Binding Protein 1AFKBP-12FKBP12GoalsHalf-CystineHuman GenomeL-CysteineL-LysineL-SerineLigandsLysineMacrophilin-12Metabolic Protein DegradationModalityMolecularProtein Degradation InductionProtein TurnoverProteinsProteomicsPublishingRegulatory Protein DegradationResearchSeriesSerineTacrolimus Binding Protein 1ATherapeuticTissuesTyrosineUbiquitilationUbiquitin Protein LigaseUbiquitin-Protein Ligase ComplexesUbiquitin-Protein Ligase E3UbiquitinationUbiquitinoylationadductbiocompatibilitybiomaterial compatibilitychemoproteomicsdesigndesigningdevelopmentalhuman whole genomeinterestnew approachesnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generationnext generation therapeuticsnovelnovel approachesnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel strategiesnovel strategynovel therapeuticsnovel therapypharmacologicprotein degradationrecruitsmall moleculeubiquinationubiquitin conjugationubiquitin-protein ligase
Description preview
Project Summary
Targeted protein degradation (TPD) is an emerging therapeutic modality with the potential to overcome
limitations of traditional pharmacological inhibition approaches. TPD uses small molecules (degraders) to hijack
the cellular degradation machinery by recruiting E3 ubiquitin ligases to proteins of interest (POI), which would
not…
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