grant
Chemical Probes to Study Methionine Redox Biology
Organization PRINCETON UNIVERSITYLocation Princeton, UNITED STATESPosted 15 Jul 2020Deadline 31 May 2028
NIHUS FederalResearch GrantFY2025Amino AcidsAntioxidantsAutoregulationBiochemicalBiological MimeticsBiologyBiomimeticsBody TissuesBusiness-Friendly AtmosphereCancer cell lineCancersCell BodyCell Communication and SignalingCell FractionationCell Growth in NumberCell LineCell MultiplicationCell ProliferationCell SignalingCell modelCellLineCellsCellular Metabolic ProcessCellular ProliferationCellular modelChemicalsChemistryCoenzyme IIComplexCysteineD-GlucoseDNA mutationDataData SetDegenerative Neurologic DisordersDevelopmentDextroseDiseaseDisorderDrug Metabolic DetoxicationDrug Metabolic DetoxificationEctopic ExpressionEndowmentEngineeringEnzyme GeneEnzymesFree EnergyGenetic ChangeGenetic defectGenetic mutationGlucoseGlycolysisH2O2Half-CystineHealthHexose Monophosphate ShuntHomeostasisHydrogen PeroxideHydroperoxideImageIntermediary MetabolismIntracellular Communication and SignalingInvestigatorsIsotopesKnock-outKnockoutL-CysteineLC/MSLabelLinkMalignant CellMalignant NeoplasmsMalignant TumorMapsMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMetabolicMetabolic Drug DetoxicationsMetabolic ProcessesMetabolismMetabolism of Toxic AgentsMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic TumorMethionineMethodsModelingMutationNAD phosphateNAD(H) phosphateNADH phosphateNADPNADPHNMR SpectrometerNMR SpectroscopyNeoplasm MetastasisNerve DegenerationNervous System Degenerative DiseasesNeural Degenerative DiseasesNeural degenerative DisordersNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNeuron DegenerationNicotinamide-Adenine Dinucleotide PhosphateNitrogenOncogenicOrganism-Level ProcessOrganismal ProcessOxidantsOxidation-ReductionOxidative StressOxidative Stress InductionOxidizing AgentsPathologicPathologyPathway interactionsPentose Phosphate PathwayPentose Phosphate ShuntPentose ShuntPentosephosphate PathwayPentosephosphate ShuntPhasePhosphatesPhysiologicPhysiologic ProcessesPhysiologicalPhysiological HomeostasisPhysiological ProcessesPhysiologyPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingPropertyProtein ModificationProteinsProteomeProteomicsPyruvate KinaseReagentRedoxRegulationResearch PersonnelResearchersResistanceRespirationS elementSecondary NeoplasmSecondary TumorShuntShunt DeviceSignal TransductionSignal Transduction SystemsSignalingSiteSpecificityStrains Cell LinesSulfoxideSulfurSurfaceTechniquesTestingThrombosisTimeTissuesTrainingTriphosphopyridine NucleotideVascular DiseasesVascular Disorderactivity-based protein profilingadductaminoacidbiological signal transductionblood vessel disorderbusiness-friendly environmentcancer cellcancer metastasiscell metabolismcellular metabaolismchemoproteomicscollaborative atmospherecollaborative environmentcomputer based predictioncultured cell linedegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdesigndesigningdesthiobiotindethiobiotindetoxificationdevelopmentalelectron acceptorgenome mutationimagingimprovedinnovateinnovationinnovativeinorganic phosphateinteractive atmosphereinteractive environmentinterdisciplinary atmosphereinterdisciplinary environmentlife spanlifespanliquid chromatography mass spectrometrylung cancer cellmalignancymethionine sulfoxidemethionine sulfoxide reductasemodel designmultiomicsmultiple omicsmutantneoplasm/cancerneural degenerationneurodegenerationneurodegenerativeneurodegenerative illnessneurological degenerationneuronal degenerationnovelnuclear magnetic resonance spectroscopyoxaziridineoxidationoxidation reduction reactionpancreatic cancer modelpancreatic tumor modelpanomicspathwaypeer-group atmospherepeer-group environmentpeptide methionine sulfoxide reductasephosphoenol transphosphorylasephosphoenolpyruvate kinasepredictive modelingprotein functionprotein purificationpublic health relevanceresistantrespiratory mechanismresponseshuntssubcellular fractionationthrombotic diseasethrombotic disordertooltumor cell metastasisvascular dysfunctionvasculopathy
Description preview
Project Summary/Abstract
Protein methionine residues are emerging as essential redox sites for physiological processes spanning signal
transduction, antioxidant defense, and regulation of protein function. At the same time, aberrant elevations in
methionine oxidation induced by oxidative stress and/or inactivation of methionine sulfoxide reductase…
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