grant
Chemical probes for imaging and treatment of otitis media
Organization STANFORD UNIVERSITYLocation STANFORD, UNITED STATESPosted 1 Aug 2025Deadline 31 Jul 2029
NIHUS FederalResearch GrantFY20250-11 years oldActinotherapyActive SitesAcuteAddressAnti-Bacterial AgentsAntibiotic AgentsAntibiotic DrugsAntibioticsAntimicrobial ResistanceAssayB catarrhalisB. catarrhalisBacteriaBacterial InfectionsBindingBioassayBiochemicalBiological AssayBlood PlasmaBranhamella catarrhalisCarboxypeptidaseCell BodyCell Communication and SignalingCell SignalingCell WallCell membraneCellsChemicalsChildChild YouthChildhoodChildren (0-21)ChronicColoring AgentsCustomCytoplasmic MembraneD pneumoniaeD. pneumoniaeDetectionDevelopmentDiagnosisDiplococcus pneumoniaeDyesEarEngineeringEnzyme GeneEnzymesEsteroproteasesFluorescenceFoundationsGeneHomologGeneralized GrowthGlycopeptidesGoalsGrowthH influenzaeH. influenzaeHaemophilus influenzaeHomologHomologous GeneHomologueHumanImageImaging DeviceImaging InstrumentImaging ToolImmune mediated therapyImmunologically Directed TherapyImmunotherapyIn VitroInfectionInflammationInjectionsIntracellular Communication and SignalingLabelLactone CompoundLactonesLeadLibrariesLightLight TherapyLipopolysaccharidesM catarrhalisM. catarrhalisMeasuresMethodsMicroscopyMiscellaneous AntibioticModelingModern ManMolecular InteractionMoraxella catarrhalisMultiple Anti-bacterial Drug ResistanceMultiple Anti-bacterial Drug ResistantMultiple Bacterial Drug ResistanceOtitis MediaOtoscopesOtoscopyP aeruginosaP. aeruginosaPUVAPUVA PhotochemotherapyPb elementPenicillinsPeptidasesPeptide HydrolasesPhotochemotherapyPhotodynamic TherapyPhotoradiationPhotoradiation TherapyPhotosensitizersPhotosensitizing AgentsPhototherapyPlasmaPlasma MembranePlasma SerumPneumococcusProtease GeneProteasesProteinasesProteolytic EnzymesPseudomonas aeruginosaPseudomonas pyocyaneaReaderResearchResidualResidual stateResistance developmentResistance to Multiple Anti-bacterial DrugResistant developmentResistant to Multiple Anti-bacterial DrugReticuloendothelial System, Serum, PlasmaRiskS aureusS pneumoniaeS. aureusS. pneumoniaeSensitivity and SpecificitySignal TransductionSignal Transduction SystemsSignalingStaph aureusStaphylococcus aureusStreptococcus pneumoniaeTestingTimeTissue GrowthToxic effectToxicitiesTreatment EfficacyTreatment FailureUnited StatesViral DiseasesVirus DiseasesWorkanti-bacterialanti-microbial resistantbacteria infectionbacterial diseasebeta lactam antibioticbeta-Lactamsbiological signal transductioncostcovalent bondcustomscytotoxicdeveloping resistancedevelopmentaldiagnostic approachdiagnostic strategydiagnostic tooleffective therapyeffective treatmentefficacy testingexposure to lightexposure to visible lightfluorescence imagingfluorescent imagingheavy metal Pbheavy metal leadimagingimaging probeimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyimprovedintervention efficacykidslight exposurelight interventionlight pollution exposurelight treatmentmedia consumptionmedia usemiddle earmiddle ear infectionmouse modelmulti-drug resistant bacteriamultidrug resistant bacteriamurine modelnano-molarnanomolarneoplasm/cancer photoradiation therapynew approachesnew diagnosticsnext generation diagnosticsnovelnovel approachesnovel diagnosticsnovel strategiesnovel strategyontogenypediatricphosphonatephotosensitizerplasmalemmapreventpreventingrapid detectionrapid diagnosisresistance to anti-microbialresistant to antimicrobialresponsesmall molecular inhibitorsmall molecule inhibitorsuccesstargeted imagingtherapeutic efficacytherapy efficacytherapy failuretooltreatment strategyvalidation studiesviral infectionvirus infectionvirus-induced diseaseyoungsterβ lactam antibioticβ-Lactams
Description preview
Project Summary
Otitis media (OM), or infection of the middle ear, is the second most common illness diagnosed in children in
the United States. It results in greater than $2 billion in costs per year and is responsible for 24% of all pediatric
antibiotic prescriptions. Acute OM is most commonly caused by the bacteria Streptococcus pneumoniae,…
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