grant
Chemical biology of voltage-gated cation channels
Organization UNIVERSITY OF IOWALocation IOWA CITY, UNITED STATESPosted 1 Feb 2023Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY2025AdoptedAmplifiersArrhythmiaBindingBinding SitesBiologicalBiologyCalcium ChannelCalcium Channel Antagonist ReceptorCalcium Channel Blocker ReceptorsCalcium Ion ChannelsCardiacCardiac ArrhythmiaCardiac ChronotropismCationsCell BodyCell Communication and SignalingCell SignalingCell membraneCellsChemicalsChemistryClinicalCombining SiteCytoplasmic MembraneDissectionDrugsEnvironmentEpilepsyEpileptic SeizuresEpilepticsEventFoundationsGoalsHeart ArrhythmiasHeart RateHeart failureHumanHypertensionIndividualIntracellular Communication and SignalingIntracellular Second MessengerIon ChannelIon Channel GatingIon Channel GatingsIonic ChannelsIonsK channelK+ elementLightLinkLong QT SyndromeMammalian CellMedicationMedicineMembraneMembrane ChannelsMethodsModern ManModificationMolecularMolecular InteractionMuscleMuscle Cell ContractionMuscle ContractionMuscle TissueMuscular ContractionNerve CellsNerve UnitNeural CellNeurocyteNeuronsPain ControlPain TherapyPain managementPathway interactionsPeptidesPerceptionPharmaceutical PreparationsPhenylalaninePhosphorylationPhotoradiationPhysiologicPhysiologicalPlasma MembranePotassium ChannelPotassium Ion ChannelsProcessProtein ConformationProtein PhosphorylationProteinsReactive SiteResearchResolutionSecond Messenger SystemsSecond MessengersSeizure DisorderShapesSignal TransductionSignal Transduction SystemsSignalingSiteSodium ChannelSodium Ion ChannelsSpeedSpinal ColumnSpineTherapeuticTyrosineVDCCVascular Hypertensive DiseaseVascular Hypertensive DisorderVertebral columnVoltage-Dependent Calcium ChannelsVoltage-Gated K+ ChannelsVoltage-Gated Potassium Channelbackbonebiologicbiological signal transductioncardiac failurechemical bindingchemical bounddrug/agentepilepsiaepileptogenicexperimentexperimental researchexperimental studyexperimentsextracellularfightinghigh blood pressurehyperpiesiahyperpiesishypertensive diseasehypertensive disorderinnovateinnovationinnovativemembrane structuremuscularneuronalpain interventionpain treatmentpathwayplasmalemmapotassium ionprogramsprotein structureprotein structuresproteins structureresolutionsresponsesensorsignal transduction second messengersskeletaltraining opportunityvoltagevoltage gated channel
Description preview
Voltage-gated ion channels shape electrical signaling in the excitable cells of nerve and muscle. Sodium (NaV)
and calcium channels (CaV) drive membrane depolarization and activate second messenger pathways via gated
cellular entry of their namesake ions. In skeletal and cardiac cells, CaV channels trigger muscle contraction.
Voltage-gated…
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