grant
Characterizing Lung Resident B1 cells and their Impact on Lung Homeostasis during Development
Organization TUFTS UNIVERSITY BOSTONLocation BOSTON, UNITED STATESPosted 1 Feb 2025Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY202519S Gamma GlobulinAb responseAgingAlveolarAlveolar MacrophagesAlveolusAnatomic SitesAnatomic structuresAnatomyAntibodiesAntibody FormationAntibody ProductionAntibody RepertoireAntibody SpecificityAntibody-Secreting CellsAntigensApoptoticAssayAutoantigensAutologous AntigensAutomobile DrivingAutoregulationB blood cellsB cellB cell receptorB cellsB-Cell Antigen ReceptorB-Cell SubsetsB-CellsB-Lymphocyte SubsetsB-LymphocytesB-cellBioassayBiological AssayBirthBlood Plasma CellBody TissuesBone MarrowBone Marrow Reticuloendothelial SystemBronchial AlveolusC57BL/6 MouseCD19CD19 geneCITE sequencingCITE-seqCITEseqCSIFCSIF-10CategoriesCell BodyCellsCellular Indexing of Transcriptomes and Epitopes by SequencingCharacteristicsClassificationCytokine Synthesis Inhibitory FactorDataData SetDevelopmentDiseaseDisorderELISAEmbryoEmbryonicEnvironmentEnzyme-Linked Immunosorbent AssayEpithelial CellsExpression SignatureFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryGene Expression ProfileGene TranscriptionGenetic TranscriptionGerm LinesGreater sac of peritoneumHematopoiesisHematopoietic Cellular Control MechanismsHistologicHistologic TechnicsHistologic TechniquesHistological TechnicsHistological TechniquesHistologicallyHomeostasisIL-10IL10IL10AIg Somatic HypermutationIgAIgMImmuneImmune responseImmunesImmunityImmunoglobulin AImmunoglobulin MImmunoglobulin Somatic HypermutationImmunoglobulin-Secreting CellsImmunologic SubtypingImmunomodulationImmunophenotypingIn VitroInfectionInflammationInjuryInnate Immune ResponseInnate ImmunityInterleukin 10 PrecursorInterleukin-10Lamina PropriaLifeLocationLungLung Alveolar EpitheliaLung ParenchymaLung Respiratory SystemLung SurfactantLung TissueLung infectionsMediatingMiceMice MammalsModelingMucosaMucosal ImmunityMucosal TissueMucous MembraneMurineMusMyelogenousMyeloidNative ImmunityNatural ImmunityNon-Specific ImmunityNonspecific ImmunityParturitionPathway interactionsPeritoneal CavityPeritoneumPhagocytosisPhenotypePhysiological HomeostasisPlasma CellsPlasmacytesPlayPopulationProcessPropertyPulmonary MacrophagesPulmonary SurfactantsRNA ExpressionRegulationResearchResolutionRespiratory physiologyRestRoleSelf-AntigensSentinelShapesSiteSmall IntestinesSortingSpecificitySpleenSpleen Reticuloendothelial SystemStructure of parenchyma of lungSystematicsTestingTissuesTranscriptionadaptive immune responsealveolar epitheliumantibody biosynthesisblood cell formationcellular indexing of transcriptomes and epitopes by single cell sequencingchronic inflammatory diseasecytokinedevelopmentaldrivingenzyme linked immunoassayexperimentexperimental researchexperimental studyexperimentsflow cytophotometrygene expression patterngene expression signaturegene signaturesgenetic signaturehigh dimensionalityhost responseimmune modulationimmune regulationimmune system responseimmunogenimmunoglobulin biosynthesisimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryimmunoresponseinfancyinfantileinflammatory lung diseaseinjuriesinjury to tissuelife spanlifespanlung developmentmucosal sitenatural antibodiesnovelpathwayplasmocytepostnatalprogramspulmonarypulmonary infectionsrecruitresidenceresidential buildingresidential siteresolutionsrespiratory functionscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsmall bowelsocial rolesomatic hypermutationspatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicstissue injurytranscriptional profiletranscriptional signature
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PROJECT ABSTRACT
Tissue resident innate immune cells contribute to lung homeostasis by orchestrating local immunity and
regulating inflammation in a tissue-specific manner. Thus far, characterization of homeostatic mechanisms has
been largely focused on myeloid populations, but the contribution of other innate immune cells to homeostasis
is still…
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