grant
Characterizing genetic risk of cancer across diverse populations through multi-ancestry epigenome profiling and chromatin QTL discovery
Organization DANA-FARBER CANCER INSTLocation BOSTON, UNITED STATESPosted 1 Apr 2025Deadline 31 Mar 2030
NIHUS FederalResearch GrantFY2025AffectAfricaAfrican AmericanAfrican ancestryAfrican descentAfro AmericanAfroamericanAsian groupAsian individualAsian peopleAsian populationAsiansBiologicalBlood PlasmaBreast CancerCancersCell BodyCellsChIP SequencingChIP-seqChIPseqChromatinClinicalColon CancerColon CarcinomaDNADataData SetDeoxyribonucleic AcidDevelopmentDiseaseDisorderDisparitiesDisparityDisproportionate number of menDisproportionately impacts malesDisproportionately in menEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEquityEuropean ancestryGWA studyGWASGene Action RegulationGene Expression RegulationGene FrequencyGene RegulationGene Regulation ProcessGene variantGeneticGenetic DiversityGenetic RiskGenetic VariationGenetic studyGenotypeGoalsHispanic PopulationsHispanic groupHispanic individualHispanic peopleHispanicsIncidenceIndividualInequalityInvestigatorsLatinoLatino PopulationLatino groupLatino individualLatino peopleLatinosLinkage DisequilibriumLocalized DiseaseMalignant Breast NeoplasmMalignant NeoplasmsMalignant TumorMalignant Tumor of the LungMalignant neoplasm of lungMalignant neoplasm of prostateMalignant prostatic tumorMeasuresMedicineMethodsNatureOncologyOncology CancerPaperPatient Self-ReportPerformancePersonsPlasmaPlasma SerumPopulationPopulation HeterogeneityProstate CAProstate CancerProstate malignancyPulmonary CancerPulmonary malignant NeoplasmQTLQuantitative Trait LociRegulatory ElementReproducibilityResearch PersonnelResearchersReticuloendothelial System, Serum, PlasmaRiskRisk-associated variantSamplingScreening for cancerSelf-ReportSpeedStructureTestingUnderrepresented GroupsUnderrepresented PopulationsVariantVariationallelic frequencyallelic variantbiologiccancer cell genomecancer genomecancer in the coloncancer riskchromatin immunoprecipitation coupled with sequencingchromatin immunoprecipitation followed by sequencingchromatin immunoprecipitation with sequencingchromatin immunoprecipitation-seqchromatin immunoprecipitation-sequencingclinical applicabilityclinical applicationcohortdevelopmentaldisease causing variantdisease riskdisease-causing alleledisease-causing mutationdisorder riskdisproportionately affects malesdisproportionately affects mendisproportionately concentrated among mendisproportionately distributed among mendisproportionately higher among mendisproportionately impacts mendisproportionately occurs in mendiverse populationsearly cancer detectionepigeneticallyepigenome profilingepigenomic profilingepigenomicsgenetic associationgenetic variantgenome scalegenome wide associationgenome wide association scangenome wide association studygenome-widegenomewidegenomewide association scangenomewide association studygenomic variantheterogeneous populationhistone modificationimprovedinnovateinnovationinnovativeinsightlow-frequency mutationlung cancermale biasmale predominancemalignancymalignant breast tumormenmen disproportionately diagnosedmen disproportionately experiencemen experience disproportionate ratesmulti-ethnicmultiethnicneoplasm/cancernew approachesnovelnovel approachesnovel strategiesnovel strategypathogenic allelepathogenic variantpolygenetic risk scorespolygenic risk scorepopulation diversitypredominantly affecting menprostate cancer riskracial diversityracially diverserare allelerare mutationrare variantrisk allelerisk generisk genotyperisk locirisk locusrisk variantscreening cancer patientsstudy populationtumor genomeunder representation of groupsunder represented groupsunder represented peopleunder represented populationsunderrepresentation of groupsunderrepresented peoplewhole genome association analysiswhole genome association study
Description preview
PROJECT SUMMARY
Multi-ancestry genome-wide association studies (GWAS) are beginning to identify cancer risk loci that are
associated with genetic ancestry. Most GWAS risk loci affect regulatory DNA, and it remains challenging to
determine how genetic variants at these loci alter gene regulation to confer cancer risk. Chromatin QTLs
(cQTLs) are…
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